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The Journal of Cell Communication and Signaling publishes fundamental and translational research into
intercellular and intracellular signaling pathways.

The Journal of Cell Communication and Signaling will be the Gold Open Access official journal of the International CCN Society.

The first issue of JCCS that will be published by Wiley in January 2024

will be Issue 1 of Volume 18, in continuation of previous numbering.

The content of JCCS issues will be posted on this page.

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Who are we?


The International CCN Society (ICCNS) was created in 2001 after the First International Workshop on the CCN Family of Genes held in St Malo, 17-19 October, 2000.

The ICCNS welcomes you. 

Tweet #ICCNSpresident

Six regulatory proteins involved in cell communication and signaling were originally designated by the CCN acronym [for Connective tissue growth factor (CTGF), Cystein-rich protein (Cyr61) and Nephroblastoma overexpressed (nov)]. They are involved in fundamental biological processes such as cell adhesion and migration, angiogenesis, development and signaling in normal and pathological conditions.

The official unified nomenclature adopted by the HGNC (Perbal B, Tweedie S, Bruford E. (2019) calls for the use of the acronyms, CCN1-6, and discontinuation in the use of CYR61, CTGF, NOV and WISP 1-3 respectively. [J Cell Commun Signal. (2018) 4:625-629]

It is important that both research teams who are newcomers and leaders in this field meet on a regular basis to discuss future prospects and unify their efforts in order for the CCN field to become highly interactive. The main goal of the International CCN Society is to foster the gathering of scientists interested in cell communication and signaling. Every other year since 2000, the ICCNS has organized the International Workshops on the CCN family of genes, open to Graduate students, Post Docs and PIs . These meetings have been acclaimed by all attendees who appreciated this family-type of meeting which provides a unique opportunity for young ones to meet leaders and building collaborations at all levels. It has recently been proposed that other families of regulatory factors participating in cell communication and signaling be considered as CCN proteins at large [Perbal B et al. J. Cell. Commun. Signal. (2023) 17:229-232].


The main goals of the society are to:

  • Provide comprehensive information related to the field of the CCN genes and proteins.
  • Facilitate and organize the CCN workshops and other related meetings.
  • Facilitate and promote the distribution of reagents among the CCN community.
  • Promote contacts with others scientific societies.
  • Provide a forum for discussion and interaction.
  • Promote the dissemination of scientific information through the publication of the Journal of Cell Communication and Signaling.


The International CCN Society is a non-profit association.

The Executive Board of the International CCN Society is in charge of the representation, and administration of the ICCNS. It is the interlocutor for JCCS and International meetings affairs. 

It is comprised of:

The President and Treasurer of the ICCNS are permanent members of the Council and Advisory Scientific Committee.

The Council of the International CCN Society is acting as an advisory committee to help the executive board in taking decisions regarding the scientific organization of the Society. It is in charge of promoting the scientific connections between the ICCNS and other scientific, medical and pharmaceutical societies worldwide, and participate to the widening of the ICCNS expertise.

The Council reports to the ICCNS Executive Board.

Members of the Council include


The Advisory Scientific Committee of the International CCN Society is in charge of proposing and reviewing the operations of the ICCNS from a scientific angle. 

Satoshi KUBOTA has been nominated President of the Advisory Scientific Committee, starting October, 15th, 2023

After consultations with members of the ICCNS, and in order to initiate contacts and stimulate interactions between the ICCNS and other scientific societies, the President of the Executive Board have commissioned the following colleagues who kindly accepted to act as active members of the Advisory Scientific Committee:

Havard ATTRAMADAL, Rob BAXTER, Celina KLEER, Zhiyong LIN, Kunimasa OHTA, and Katia SCOTLANDI

Honorary Membership

Honorary Membership is offered to distinguished individuals who have made highly recognized contributions to the scientific community.

Members of the ICCNS Council can recommend candidates for this prestigious type of membership, on the basis of outstanding research activity or exceptional leadership.

Nominations will be examined by members of the ICCNS Council and external advisors who will be selected by the President of the ICCNS. The Honorary members are invited by the President of the ICCNS.

In recognition of the important commitments and contributions made to the benefit of the ICCNS, the workshops, and to the the CCN field of science, we are very pleased to recognize Lester LAU and David BRIGSTOCK with an honorary lifetime membership, starting Jan 2020, with all intended benefits of membership in the ICCNS

Honorary Membership is also offered by the President of ICCNS to all Recipients of the ICCNS Award.


Professor Paul Bornstein (2008-2013), Professor Edward Calabrese, Professor Robert Baxter, Professor Carlo Croce, Professor Judith Campisi , Professor Meenhard Herlyn, Professor Cynthia Kenyon, Professor Lester Lau

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Next meeting

The 12th workshop on the CCN family of genes meeting will be held

in Oslo, Norway


Foto: VisitOSLO/Didrick Stenersen
Foto: VisitOSLO/FaraMohri
Foto: VisitOSLO/Didrick Stenersen

More information available soon on
this site

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A brainstorming meeting was organized by the International CCN Society

on April 4th, 2022  in Nice France

This meeting was aimed to discuss proposals of the ICCNS to organize joint meetings and foster interactions with other scientific and medical societies sharing our interest in all aspects of cellular communication. 

The major goal of the non-profit ARBIOCOM (Association for Research on Biosignaling and Communication) is to foster the reunion of scientific societies members interested in cellular signaling at all levels, including: cellular signal transduction, intercellular communication, communication with the microenvironment, but also remote communication involving soluble circulating factors, hormones, extracellular vesicles, and communication between cells and organs in response to bacterial and viral infection.
The brainstorming meeting members examined the possibility of sharing our views and take this unique opportunity to join our efforts and develop new comprehensive approaches, in a friendliness environment.

Thanks to the very productive intellectual blending and positive personal interactions that occurred during this meeting, it was agreed that the ARBIOCOM would provide the ground for a federation of societies and their journals into a “network”, where each society remains independent entities, in order to promote collaborative research in cell signaling and communication, in healthy and pathological processes and disseminate new research findings via publication and via formal and informal meetings.

A steering Committee was set up

Chair : Bernard Perbal

Carlo Croce

Ali Mobasheri

Representatives  from:

the Bristish Society of Matrix Biology

the International Society of Matrix Biology

Editors in chief of JCCS and CCS

Aims to Task Force

Prepare drafts of the ARBIOCOM boards

Prepare the first 2023 ARBIOCOM meeting

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Bits and Bytes

Volumes 1-7 / 2007 – 2013

Volumes 8-11 / 2014 – 2017

Page under reconstruction

  • update in progress

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Nuts & Bolts

Nuts and Bolts


The Nuts and Bolts section welcome methods-oriented manuscripts, that address technical aspects of general interest and focus on timely matters of interest for the scientific community.

This is also a place where investigators can post technical or methodological questions, and where others can provide answers. For example, if you want to do a motility assay and are not familiar with how to do them you can post the question and anyone who wishes to provide help can respond on the website. We appreciate that it is a time-consuming service to provide such information, and we will do our best to see that all technical comments or discussions on a technical point find their way into the JCCS.


August 2008

  • Enzymes Used In Molecular Biology: A Useful Guide (L. Rittié and B. Perbal)

March 2009

  • A rapid and Sensitive Method for Measuring Cell Adhesion (W. Lu, L. McCallum and A. E. Irvine)

January 2014

  • Patentability of computer programs (B. Perbal)

Updating in progress