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EDITORIAL :

A SPECIAL ISSUE ON CCN PROTEINS AND CANCER

With this special issue we celebrate 25 years of publishing in the field of CCN protein biology. Since the very first publications reporting the existence of these proteins, strong relationships have been established between the disregulation in the expression of CCN proteins and the development of cancer.

The existence of positive and negative regulators of cell proliferation and differentiation exibited by the members that constitute the CCN family soon appeared to be a salient feature of this group of structurally related proteins, and raised challenging questions regarding their specific role in tumor initiation, promotion and progression.  Some of the family members  have been shown to increase the metastatic potential of tumor cells whereas others behave as tumor suppressors and/or antimetastatic agents.  

To celebrate the recent assignment to JCCS of a noteworthy IF (3.123 in 2015), we have invited several colleagues involved in cancer research to review specific aspects of this important disease.  We have also taken the opportunity of recognizing the 25th CCN publishing anniversary to evaluate the impact of the CCN field through an analysis of the number of articles published since the discovery of the first members of the CCN family.

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