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CCN Express

CCN Express

The members of the CCN family are capable of eliciting and modifying a wide range of biological activities through their ability to modify adhesive signaling via integrins and heparan sulfate-containing proteoglycans. The CCN proteins can be considered therefore to be part of a larger category of matricellular proteins. To widen the scope of the intellectual inquiry into the CCN family as well as to increase the interest in the CCN field as a whole, with this issue the CCN Society initiates a section of its newsletter called CCN Express. In this section of the newsletter, both established and new investigators will be invited to provide their opinions on topics related to the role and function of CCN proteins as well as related matricellular molecules in development, homeostasis and disease.

Issue 03 - January 2009

Welcome to the first edition of the CCN Society newsletter for 2009.

In this issue, Roger Mason presents a review article on the possible role of CCN2 (connective tissue growth factor, CTGF) in diabetic nephropathy This review is extremely timely as there is a very strong interest currently in developing anti-CCN2 therapies to treat this disorder.

Connective tissue growth factor (CCN2), a pathogenic factor in diabetic nephropathy. What does it do? How does it do it? (Roger Mason)

Issue 02 - August 2008

This month brings the second edition of our new, quarterly newsletter. This is the last issue prior upcoming 5th International Workshop on the CCN family of Genes in Toronto and I encourage the reader to attend this meeting in a truly dynamic, international city.

In this issue, for the CCN Express portion of the Newsletter, Mark Erwin of the University of Toronto has written a timely review on an interesting topic, namely the possible role that CCN2 might play in development of the notochord and early chondrogenesis. Also in this issue, Bernard Perbal has written a timely review on CCN3, and addresses apparent controversies in the literature regarding the function of CCN3 in cancer.

CCN2 might play in development of the notochord (Mark Erwin)

CCN3 : Doctor JEKYLL and Mister HYDE (Bernard Perbal)

I hope that these articles spawn discussion via the internet (you are encouraged to contact the editors of the CCN Society website) and in Toronto.

Issue 01 - July 2008

Functional Role of Periostin Expression in Development and Wound Repair: Implications for Connective Tissue Disease.

Comprehensive review by Dr Douglas Hamilton, on the potential role of periostin, a fairly novel multifunctional matricellular glycoprotein.

In future issues, there will be reviews on the role of CCN2 in both chondrogenesis and in diabetes. We hope that the CCN Express will emphasize the key roles that CCN and related proteins play, as well as spark new insights into the function of individual proteins.

Best wishes,

Andrew Leask, PhD