Vice President for Asian countries
Masaharu Takigawa, PhD
Department of Biochemistry and Molecular Biochemistry
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
2-5-1, Shikata-cho, Okayama, 600-8525,
JAPAN
Tel: 81-86-235-6645
Fax: 81-86-235-6649
http://www.dent.okayama-u.ac.jp/...
Present Position
Professor, Department of Biochemistry and Molecular Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Societies
The International CCN Society (First member)
International Bone and Mineral Society
Japanese Society of Cartilage Metabolism (board of directors)
Japanese Society for Bone and Mineral Metabolism (councilor, board of directors -2007)
Japanese Association for Oral Biology (councilor, board of directors -2006)
The Japanese Biochemical Society (councilor)
Japanese Society for Connective Tissue Research (councilor)
The Japanese Vascular Biology and Medicine Organization (councilor)
The Molecular Biology Society of Japan
The Japanese Cancer Association
Japan Society for Cell biology
American Society for Bone and Mineral Research
American Society for Biochemistry and Molecular Biology
American Association for Cancer Research
American Association for the Advancement of Science
Awards
1992 Scientific Award from Japanese Society for Bone and Mineral Metabolism
1997 Promotion Award of Bone and Joint Disease from the Japan Rheumatism Foundation
Editorial Boards
Journal of Cell Communication and Signaling (Deputy editor)
Journal of Oral Biosciences (Editor in Biochemistry)
Journal of Bone and Mineral Metabolism (Advisory board)
Current Research
- The roles of CCN proteins in skeletal growth and regeneration
- CCN2 actions in angiogenesis and tumor growth
- Molecular Mechanism of endochondral ossification and cartilage growth and regeneration
Selected Recent Publications
Kawaki H , Kubota S, Suzuki A, Lazar N, Yamada T, Matsumura T, Ohgawara T, Maeda T, Perbal B, Lyons K, Takigawa M
Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 revealed by a comprehensive analysis of the CCN family proteins in cartilage
J. Bone Miner. Res. 2008 ; in press
Eguchi T, Kubota S, Kawata K, Mukudai Y, Uehara J, Ohgawara T, Ibaragi S, Sasaki S, Kuboki T, and Takigawa M
Novel transcription factor-like function of human MMP3 regulating CTGF/CCN2 gene
Mol. Cell. Biol. 2008;28:2391-413.
Kikuchi T, Kubota, S, Asaumi K, Kawaki H, Nishida T, Kawata K, Mitani S, Tabata Y, Ozaki T, and Takigawa M Promotion of bone regeneration by CCN2 incorporated into gelatin hydrogel
Tissue Eng. 2008; in press
Ono M, Kubota S, Fujisawa T, Sonoyama W, Kawaki H, Akiyama K, Oshima M, Nishida T, Yoshida Y, Suzuki K, Takigawa M, and Kuboki T
Promotion of hydroxyapatite-associated, stem cell-based bone regeneration by CCN2.
Cell Transplantation 2008;17:231-40.
Fujisawa T, Hattori T, Ono M, Uehara J, Kubota, S, Kuboki T, and Takigawa M
CCN family 2 / Connective tissue growth factor (CCN2/CTGF) stimulates proliferation and differentiation of auricular chondrocytes.
Osteoarthritis Cartilage 2008; in press
Kawaki H, Kubota S, Suzuki A, Yamada T, Matsumura T, Mandai T, Yao M, Maeda T, Lyons KM, Takigawa M.
Functional requirement of CCN2 for intramembranous bone formation in embryonic mice.
Biochem. Biophys. Res. Commun. 2008;366:450-6.
Oka M, Kubota S, Kondo S, Eguchi T, Kuroda C, Kawata K, Minagi S, Takigawa M.
Gene expression and distribution of connective tissue growth factor (CCN2/CTGF) during secondary ossification center formation.
J. Histochem. Cytochem. 2007;55:1245-55.
Koitabashi N, Arai M, Niwano K, Watanabe A, Endoh M, Suguta M, Yokoyama T, Tada H, Toyama T, Adachi H, Naito S, Oshima S, Nishida T, Kubota S, Takigawa M, and Kurabayashi M
Plasma connective tissue growth factor is a novel potential biomarker of cardiac dysfunction in patients with chronic heart failure.
Eur. J. Heart Fail. 2008;10:373-9.
Kubota S, and Takigawa M
Role of CCN2/CTGF/Hcs24 in Bone Growth.
Int. Rev. Cytol. 2007; 147: 1-41. Review.
Kubota S, and Takigawa M
CCN2 Molecule Page UCSD/Nature. The Signaling Gateway. 2007; AfCS ID A003961:
URL: http://www.signaling-gateway.org/molecule/query?afcsid=A003961
Kubota S, and Takigawa M
CTGF (connective tissue growth factor). Atlas Genet Cytogenet Oncol Haematol. 2007; CTGFID40192.
URL: http://AtlasGeneticsOncology.org/Genes/CTGFID40192ch6q23.html
Kubota S, Takigawa M.
CCN family proteins and angiogenesis: from embryo to adulthood.
Angiogenesis. 2007;10:1-11. Review.
Kubota S, Yeger H, Perbal B, Takigawa M.
Report on the fourth international workshop on the CCN family of genes.
J. Cell Commun. Signal. 2007 Jun;1:59-65.
Miyamoto Y, Mabuchi A, Shi D, Kubo T, Takatori Y, Saito S, Fujioka M, Sudo A, Uchida A, Yamamoto S, Ozaki K, Takigawa M, Tanaka T, Nakamura Y, Jiang Q, Ikegawa S.
A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis.
Nat. Genet. 2007; 39:529-33. Epub 2007 Mar 25.
Eguchi T, Kubota S, Kawata K, Mukudai Y, Ohgawara T, Miyazono K, Nakao K, Kondo S, and Takigawa M
Different transcriptional strategies of ccn2/ctgf gene induction between human chondrocytic and breast cancer cell lines.
Biochimie, 2007; 89: 278-288
Yanagita T, Kubota S, Kawata K, Kawaki H, Kondo S, Takano-Yamamoto T, Tanaka S. and Takigawa M
Expression and physiological role of CCN4/Wnt-induced secreted protein 1 mRNA splicing variants in chondrocytes
FEBS J. 2007; 274:1655-1665.
Koitabashi N, Arai M, Kogure S, Niwano K, Watanabe A, Aoki Y, Maeno T, Nishida T, Kubota S, Takigawa M, and Kurabayashi M
Increased connective tissue growth factor relative to brain natriuretic peptide as a determinant of myocardial fibrosis.
Hypertension 2007; 49:1120-1127.
Ono M, Kubota S, Fujisawa T, Sonoyama W, Kawaki H, Akiyama K, Oshima M, Nishida T, Yoshida Y, Suzuki K, Takigawa M, Kuboki T.
Promotion of attachment of human bone marrow stromal cells by CCN2.
Biochem. Biophys. Res. Commun. 2007;357(1):20-5.
Nishida T, Kawaki H, Baxter RM, Deyoung RA, Takigawa M, Lyons KM.
CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes.
J. Cell Commun. Signal. 2007 ;1(1):45-58.
Kondo S, Kubota S, Moritani N, Yosimichi G, Nishida T, Matsushita H, Matsumoto S, Kitoh T, Nakao K, Sugahara T, and Takigawa M
Hypoxic Regulation of Stability of Connective tissue growth factor/CCN2 mRNA by 3'-untranslated region interacting with a cellular protein in human chondrosarcoma cells.
Oncogene 2006; 25:1099-1110.
Shimo T, Kubota S, Eguchi T, Ibaragi S, Isowa S, Yoshioka N, Sasaki A, and Takigawa M
Pathogenic role of connective tissue growth factor (CCN2/CTGF) in osteolytic metastasis of breast cancer.
J. Bone Miner. Res. 2006; 21:1045-1059.
Yosimichi G, Kubota S, Nishida T, Kondo S, Yanagita T, Nakao K, Takano-Yamamoto T, and Takigawa M
Roles of PKC, PI3K and JNK in multiple transduction of CCN2/CTGF signals in chondrocytes.
Bone 2006; 38:853-863.
Kondo S, Tanaka N, Kubota S, Mukudai Y, Yosimichi G, Sugahara T, and Takigawa M
Novel angiogenic inhibitor DN-9693 that inhibits post-transcriptional induction of connective tissue growth factor (CTGF/CCN2) by vascular endothelial growth factor (VEGF) in human endothelial cells.
Mol. Cancer Ther. 2006; 5:129-137.
Perbal, B. and Takigawa, M. (Editors)
CCN Proteins : A New Family of Cell Growth and Differentiation Regulators. Imperial College Press, London, 2005, 1-311
Mukudai Y, Kubota S, Eguchi T, Kondo S, Nakao K, Takigawa M.
Regulation of chicken ccn2 gene by interaction between RNA cis-element and putative trans-factor during differentiation of chondrocytes.
J. Biol. Chem. 2005;280(5):3166-77. Epub 2004 Nov 18.
Nishida T, Kubota S, Kojima S, Kuboki T, Nakao K, Kushibiki T, Tabata Y, Takigawa M.
Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor).
J. Bone Miner. Res. 2004;19(8):1308-19.
Yokoi H, Mukoyama M, Nagae T, Mori K, Suganami T, Sawai K, Yoshioka T, Koshikawa M, Nishida T, Takigawa M, Sugawara A, Nakao K.
Reduction in connective tissue growth factor by antisense treatment ameliorates renal tubulointerstitial fibrosis.
J. Am .Soc. Nephrol. 2004 Jun;15(6):1430-40.
Takigawa M, Nakanishi T, Kubota S, Nishida T.
The role of CTGF/Hcs24/ecogenin in skeletal growth control.
J. Cell. Physiol. 2003;194(3):256-66. Review.
Takigawa M
CTGF/Hcs24 as a multifunctional growth factor for fibroblasts, chondrocytes, and vascular endothelial cells.
Drug News Perspect. 2003;16(1):11-21. Review.