Member
Katia Scotlandi, Ph.D.
Laboratorio di Ricerca Oncologica
Istituti Ortopedici Rizzoli
Via di Barbiano 1/10
40136 Bologna
ITALY
Tel: 051 6366 760
Fax: 051 6366 761
http://www.ior.it
Present Position
Head of the Operative Unit “Growth Factor and Receptors”
Oncology Research Laboratory
Rizzoli Institute
Professor of Biotechology
University of Bologna
Societies
Scientific Committee of the Italian Association for Cancer Research
American Association for Cancer Research
American Association for Cell Biology
International Society for IGF Research
Editorial Boards
Italian Association of Cell Culture (AICC)
Journal of Cell Communication and Signaling
Research Themes
- Genes regulating osteoblastogenesis as new therapeutic targets for bone tumors
- Targeted therapies in Ewing's sarcoma: providing new clues and tools
- Molecular therapy of bone sarcomas: the targeting of genes required for osteoblastogenesis as a new strategy
Recent Publications
Scotlandi K, Zuntini M, Manara MC, Sciandra M, Rocchi A, Benini S, Nicoletti G, Bernard G, Nanni P, Lollini PL, Bernard A, Picci P.
CD99 isoforms dictate opposite functions in tumour malignancy and metastases by activating or repressing c-Src kinase activity.
Oncogene. 2007 Apr 30; [Epub ahead of print]
Manara MC, Landuzzi L, Nanni P, Nicoletti G, Zambelli D, Lollini PL, Nanni C, Hofmann F, Garcia-Echeverria C, Picci P, Scotlandi K.
Preclinical in vivo study of new insulin-like growth factor-I receptor--specific inhibitor in Ewing's sarcoma mice.
Clin Cancer Res. 2007 Feb 15;13(4):1322-30
Manara MC, Bernard G, Lollini PL, Nanni P, Zuntini M, Landuzzi L, Benini S, Lattanzi G, Sciandra M, Serra M, Colombo MP, Bernard A, Picci P, Scotlandi K.
CD99 acts as an oncosuppressor in osteosarcoma.
Mol Biol Cell. 2006 17:1910-21. Epub 2006 Jan 18
Benini S, Zuntini M, Manara MC, Cohen P, Nicoletti G, Nanni P, Oh Y, Picci P, Scotlandi K.
Insulin-like growth factor binding protein 3 as an anticancer molecule in Ewing's sarcoma.
Int J Cancer. 2006 119:1039-46
K. Scotlandi, M.C. Manara, G. Nicoletti, P.-L. Lollini, S. Lukas, S. Benini, S. Croci, S. Perdichizzi, D. Zambelli, M. Serra, C. García-Echeverría, F. Hofmann & P. Picci.
Anti-tumor activity of the insulin-like growth factor-I receptor (IGF-IR) kinase inhibitor NVP-AEW541 in musculoskeletal tumors.
Cancer Res. 2005 65: 3868-3876
V. Cerisano, Y. Aalto, S. Perdichizzi, G. Bernard, M. C. Manara, S. Benini, G. Cenacchi, P. Preda, G. Lattanzi, B. Nagy, S. Knuutila, M. P. Colombo, A. Bernard, P. Picci, K. Scotlandi.
Molecular mechanisms of CD99-induced caspase independent -cell death and cell-cell adhesion in Ewing’s sarcoma cells: Actin and Zyxin as key intracellular mediators.
Oncogene 2004 23:5664-74
S. Benini, M.C. Manara, V. Cerisano, S. Pedichizzi, R. Strammiello, M. Serra, P. Picci, and K. Scotlandi.
The contribution of MEK/MAPK and PI3-K signaling pathway to the malignant behaviour of Ewing’s sarcoma cells: therapeutic prospects.
Int. J. Cancer 2004 108: 358-366
M. Serra, K. Scotlandi, G. Reverter-Branchat, S. Ferrari, M.C. Manara, S. Benini, M. Incaprera, F. Bertoni, M. Mercuri, A. Briccoli, G. Bacci, and P. Picci.
Value of P-glycoprotein and clinico-pathological factors as basis for new treatment strategies in high-grade osteosarcoma of the extremities.
J. Clin. Oncol. 2003 21:536-42
K. Scotlandi, M.C. Manara, R. Strammiello, L. Landuzzi, S. Benini, S. Perdichizzi, M. Serra, A. Astolfi, G. Nicoletti, P.-L. Lollini, F. Bertoni, P. Nanni & P. Picci.
c-Kit receptor expression in Ewing's sarcoma: lack of prognostic value but therapeutic targeting opportunities in appropriate conditions.
J. Clin. Oncol. 2003 21: 1952-1960
M.C. Manara, B. Perbal, S. Benini, R. Strammiello, V. Cerisano, S. Perdichizzi, M. Serra, A. Astolfi, F. Bertoni, J. Alami, H. Yeger, P. Picci, & Scotlandi K.
The expression of ccn3(nov) gene in musculoskeletal tumors.
Am J Pathol. 2002, 160: 849-859