Member
Roel Goldschmeding, M.D., Ph.D.
Department of Pathology (H04.312)
UMC Utrecht,
Heidelberglaan 100 - 3584CX Utrecht
THE NETHERLANDS
Tel: 31 887 55 65 59
Fax: 31 254 49 90
http://pathologyutrecht.nl
Present Position
Associate Professor of Pathology
University Medical Center Utrecht
Societies
Dutch Federation of Nephrology
Dutch Pathology Society
Dutch Immunology Society
Dutch Society for the Study of Diabetes
Renal Pathology Society
American Society of Nephrology
International Society of Nephrology
International CCN Society
Editorial Boards
Nephrology Dialysis Transplantation
Journal of Cell Communication and Signaling
Research Themes
- Fibrosis and regeneration
- The roles of CCN-2 in tissue response to injury
- Modulation of BMP-signaling activity by CCN-2 and other proteins
- The role of Myofibroblast progenitor cells (Fibrocytes. SPC) in tissue fibrosis
- Renal Pathology
Recent Publications
Nguyen TQ, Goldschmeding R.
Bone Morphogenetic Protein-7 and Connective Tissue Growth Factor: Novel Targets for Treatment of Renal Fibrosis?
Pharm Res. 2008 Feb 12; [Epub ahead of print]
Kuiper EJ, Roestenberg P, Ehlken C, Lambert V, van Treslong-de Groot HB, Lyons KM, Agostini HJ, Rakic JM, Klaassen I, Van Noorden CJ, Goldschmeding R, Schlingemann RO.
Angiogenesis is not impaired in connective tissue growth factor (CTGF) knock-out mice.
J Histochem Cytochem. 2007 Nov;55(11):1139-47
Kuiper EJ, de Smet MD, van Meurs JC, Tan HS, Tanck MW, Oliver N, van Nieuwenhoven FA, Goldschmeding R, Schlingemann RO.
Association of connective tissue growth factor with fibrosis in vitreoretinal disorders in the human eye.
Arch Ophthalmol. 2006 Oct;124(10):1457-62.
Wetzel P, Haag J, Câmpean V, Goldschmeding R, Atalla A, Amann K, Aigner T.
Bone morphogenetic protein-7 expression and activity in the human adult normal kidney is predominantly localized to the distal nephron.
Kidney Int. 2006 Aug;70(4):717-23.
Nguyen TQ, Chon H, van Nieuwenhoven FA, Braam B, Verhaar MC, Goldschmeding R.
Myofibroblast progenitor cells are increased in number in patients with type 1 diabetes and express less bone morphogenetic protein 6: a novel clue to adverse tissue remodelling?
Diabetologia. 2006 May;49(5):1039-48
Roestenberg P, van Nieuwenhoven FA, Joles JA, Trischberger C, Martens PP, Oliver N, Aten J, Höppener JW, Goldschmeding R.
Temporal expression profile and distribution pattern indicate a role of connective tissue growth factor (CTGF/CCN-2) in diabetic nephropathy in mice.
Am J Physiol Renal Physiol. 2006 Jun;290(6):F1344-54
Nguyen TQ, Tarnow L, Andersen S, Hovind P, Parving HH, Goldschmeding R, van Nieuwenhoven FA.
Urinary connective tissue growth factor excretion correlates with clinical markers of renal disease in a large population of type 1 diabetic patients with diabetic nephropathy.
Diabetes Care. 2006 Jan;29(1):83-8.
Andersen S, van Nieuwenhoven FA, Tarnow L, Rossing P, Rossing K, Wieten L, Goldschmeding R, Parving HH.
Reduction of urinary connective tissue growth factor by Losartan in type 1 patients with diabetic nephropathy.
Kidney Int. 2005 Jun;67(6):2325-9.
van Nieuwenhoven FA, Jensen LJ, Flyvbjerg A, Goldschmeding R.
Imbalance of growth factor signalling in diabetic kidney disease: is connective tissue growth factor (CTGF, CCN2) the perfect intervention point?
Nephrol Dial Transplant. 2005 Jan;20(1):6-10
Chuva de Sousa Lopes SM, Feijen A, Korving J, Korchynskyi O, Larsson J, Karlsson S, ten Dijke P, Lyons KM, Goldschmeding R, Doevendans P, Mummery CL.
Connective tissue growth factor expression and Smad signaling during mouse heart development and myocardial infarction.
Dev Dyn. 2004 Nov;231(3):542-50.
Kuiper EJ, Witmer AN, Klaassen I, Oliver N, Goldschmeding R, Schlingemann RO.
Differential expression of connective tissue growth factor in microglia and pericytes in the human diabetic retina.
Br J Ophthalmol. 2004 Aug;88(8):1082-7.
Roestenberg P, van Nieuwenhoven FA, Wieten L, Boer P, Diekman T, Tiller AM, Wiersinga WM, Oliver N, Usinger W, Weitz S, Schlingemann RO, Goldschmeding R.
Connective tissue growth factor is increased in plasma of type 1 diabetic patients with nephropathy.
Diabetes Care. 2004 May;27(5):1164-70.
Lam S, van der Geest RN, Verhagen NA, van Nieuwenhoven FA, Blom IE, Aten J, Goldschmeding R, Daha MR, van Kooten C.
Connective tissue growth factor and igf-I are produced by human renal fibroblast and cooperate in the induction of collagen production by high glucose.
Diabetes. 2003 Dec;52(12):2975-83
Brigstock DR, Goldschmeding R, Katsube KI, Lam SC, Lau LF, Lyons K, Naus C, Perbal B, Riser B, Takigawa M, Yeger H.
Proposal for a unified CCN nomenclature.
Mol Pathol. 2003 Apr;56(2):127-8.
Blom IE, Goldschmeding R, Leask A.
Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy?
Matrix Biol. 2002 Oct;21(6):473-82.
Chen Y, Blom IE, Sa S, Goldschmeding R, Abraham DJ, Leask A.
CTGF expression in mesangial cells: involvement of SMADs, MAP kinase, and PKC.
Kidney Int. 2002 Oct;62(4):1149-59.
Keil A, Blom IE, Goldschmeding R, Rupprecht HD.
Nitric oxide down-regulates connective tissue growth factor in rat mesangial cells.
Kidney Int. 2002 Aug;62(2):401-11.
Blom IE, van Dijk AJ, Wieten L, Duran K, Ito Y, Kleij L, deNichilo M, Rabelink TJ, Weening JJ, Aten J, Goldschmeding R.
In vitro evidence for differential involvement of CTGF, TGFbeta, and PDGF-BB in mesangial response to injury.
Nephrol Dial Transplant. 2001 Jun;16(6):1139-48.
Blom IE, van Dijk AJ, de Weger RA, Tilanus MG, Goldschmeding R.
Identification of human ccn2 (connective tissue growth factor) promoter polymorphisms.
Mol Pathol. 2001 Jun;54(3):192-6.
Ito Y, Goldschmeding R, Bende R, Claessen N, Chand M, Kleij L, Rabelink T, Weening J, Aten J.
Kinetics of connective tissue growth factor expression during experimental proliferative glomerulonephritis.
J Am Soc Nephrol. 2001 Mar;12(3):472-84.
Goldschmeding R, Aten J, Ito Y, Blom I, Rabelink T, Weening JJ.
Connective tissue growth factor: just another factor in renal fibrosis?
Nephrol Dial Transplant. 2000 Mar;15(3):296-9
Roose J, Huls G, van Beest M, Moerer P, van der Horn K, Goldschmeding R, Logtenberg T, Clevers H.
Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1.
Science. 1999 Sep 17;285(5435):1923-6.
Ito Y, Aten J, Bende RJ, Oemar BS, Rabelink TJ, Weening JJ, Goldschmeding R.
Expression of connective tissue growth factor in human renal fibrosis.
Kidney Int. 1998 Apr;53(4):853-61.
Immunol Today. 1991 Feb;12(2):61-4
Goldschmeding R, van der Schoot CE, ten Bokkel Huinink D, Hack CE, van den, Ende ME, Kallenberg CG, von dem Borne AE.
Wegener's granulomatosis autoantibodies identify a novel diisopropylfluorophosphate-binding protein in the lysosomes of normal human neutrophils.
J Clin Invest. 1989 Nov;84(5):1577-87.