Member
Karen M. Lyons, PhD
Department of Molecular, Cell & Developmental Biology
Department of Orthopaedic Surgery
University of California, Los Angeles
410C OHRC
615 Charles E Young Drive South
Los Angeles, CA 90095 USA
Tel: (310) 825-5480
Fax: (310) 206-8867
http://faculty.neuroscience.ucla.edu/institution/personnel?personnel_id=45374
Present Position
Professor of Molecular, Cell & Developmental Biology
Professor of Orthopaedic Surgery
University of California, Los Angeles
Societies
American Association for the Advancement of Science
American Society for Bone and Mineral Research
American Society for Matrix Biology
Orthopaedic Research Society
Editorial Boards
Journal of Cell Communication and Signaling
Mammalian Reproduction and Development
Fibrogenesis and Tissue Repair
Research Themes
- The roles of CCN proteins in skeletal development
- CCN2 in angiogenesis
- Fibrogenesis and Tissue Repair
Selected Recent Publications
Ivkovic, S., Yoon, B., Popoff, SN, Safadi, FF, Libuda, DE, Stephenson, RC, Daluisky, A. Lyons, K.M. .
Connective tissue growth factor is required for chondrogenesis and growth plate angiogenesis.
Development 2003;130 2779-2791.
Chuva De Sousa Lopes SM, Feijen A, Korving J, Korchynskyi O, Larsson J, Karlsson S, Ten Dijke P, Lyons KM, Goldschmeding R, Doevendans P, Mummery C. .
Connective tissue growth factor expression and Smad signaling during mouse heart development and myocardial infarction.
Dev Dyn 2004;231 542-50.
Chen, Y., Abraham, D.J., Shi-Wen, X., Black, C.M., Lyons, K.M., Leask, A.
CCN2 (Connective Tissue Growth Factor) Promotes Fibroblast Adhesion to Fibronectin.
Mol. Biol. Cell 2004;15 5635-46.
Yoon, B.S., Ovchinnikov, D.A., Yoshii, I., Mishina, Y., Behringer, R.R., Lyons, K.M.
The type I BMP receptors Bmpr1a and Bmpr1b have overlapping functions and are essential for early chondrogenesis in vivo.
PNAS (USA) 2005;102 5062-7.
Kobayashi T, Lyons KM, McMahon AP, Kronenberg HM.
BMP signaling stimulates cellular differentiation at multiple steps during cartilage development.
PNAS (USA) 2005;102 18023-7
Shi-wen X, Stanton LA, Kennedy L, Pala D, Chen Y, Howat SL, Renzoni EA, Carter DE, Bou-Gharios G, Stratton RJ, Pearson JD, Beier F, Lyons KM, Black CM, Abraham DJ, Leask A.
CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts.
J Biol Chem 2006;281 10715-26.
Wan DC, Shi YY, Nacamuli RP, Quarto N, Lyons KM, Longaker MT.
Osteogenic differentiation of mouse adipose-derived adult stromal cells requires retinoic acid and bone morphogenetic protein receptor type IB signaling.
PNAS (USA) 2006;103 12335-40.
Yoon, B.S., Ovchinnikov, D.A., Yoshii, I., Mishina, Y., Behringer, R.R., Lyons, K.M.
BMPs regulate multiple aspects of growth plate chondrogenesis through opposing actions on FGF pathways.
Development 2006;133 4667-78
Huang, B-L, Dornbach, L.M., and Lyons, K.M.
The 5' untranslated regions (UTRs) of CCN1, CCN2, and CCN4 exhibit cryptic promoter activity.
J. Cell. Commun. Signal. 2007;1 17--32.
Nihsida, T., Kawaki, H., Baxter, R., DeYoung, R.A., Lyons, K.M. .
CCN2 (Connective Tissue Growth Factor)is essential for extracellular matrix production and integrin signaling in chondrocytes.
J. Cell. Commun. Signal. 2007;1 45-58.
Kennedy L, Liu S, Shi-Wen X, Chen Y, Eastwood M, Sabetkar M, Carter DE, Lyons KM, Black CM, Abraham DJ, Leask A.
CCN2 is necessary for the function of mouse embryonic fibroblasts.
Exp. Cell Res. 2007;313 952-64.