Member
Satoshi Kubota, D.D.S., Ph.D.
Department of Biochemistry and Molecular Dentistry
Okayama University Graduate School
of Medicine, Dentistry and Pharmaceutical Sciences
2-5-1 Shikata-cho
Okayama 600-8525 JAPAN
www.dent.okayama-u.ac.jp/seika/index_sc_e.html
Present Position
Associate Professor of Biochemistry and Molecular Dentistry
Okayama University Graduate School of Medicine,
Dentistry and Pharmaceutical Sciences
Societies
International CCN Society
Japanese Society of Cartilage Metabolism (councilor)
Japanese Association for Oral Biology (councilor)
Okayama Dental Society (councilor)
The Japanese Biochemical Society
The Molecular Biology Society of Japan
Japanese Society for Bone and Mineral Metabolism
Japanese Cancer Association
Editorial Boards
Journal of Cell Communication and Signaling
Awards
1996 Junior Investigator Award, Thomas Jefferson University
2006 Scientific Award, Okayama Dental Society
Research Themes
- Investigation on the transcriptional and post-transcriptional regulation of CCN2 and the other CCN family genes
- Role and utility of CCN2 and other CCN family members in bone and cartilage regeneration
Selected Recent Publications
Eguchi T, Kubota S, Kawata K, Mukudai Y, Uehara J, Ohgawara T, Ibaragi S, Sasaki S, Kuboki T, and Takigawa M
Novel transcription factor-like function of human MMP3 regulating CTGF/CCN2 gene
Mol Cell Biol. 2008 Apr;28(7):2391-413. Epub 2008 Jan 2.
Kikuchi T, Kubota, S, Asaumi K, Kawaki H, Nishida T, Kawata K, Mitani S, Tabata Y, Ozaki T, and Takigawa M
Promotion of bone regeneration by CCN2 incorporated into gelatin hydrogel
Tissue Eng. 2008; in press
Fujisawa T, Hattori T, Ono M, Uehara J, Kubota, S, Kuboki T, and Takigawa M
CCN family 2 / Connective tissue growth factor (CCN2/CTGF) stimulates proliferation and differentiation of auricular chondrocytes.
Osteoarthritis Cartilage 2008; in press
Motoki T, Sugiura Y, Matsumoto Y, Tsuji T, Kubota S, Takigawa M, and Gohda E
Induction of hepatocyte growth factor expression by maleic acid in human fibroblasts through MAPK activation.
J. Cell. Biochem. 2008; in press
Koitabashi N, Arai M, Niwano K, Watanabe A, Endoh M, Suguta M, Yokoyama T, Tada H, Toyama T, Adachi H, Naito S, Oshima S, Nishida T, Kubota S, Takigawa M, and Kurabayashi M
Plasma connective tissue growth factor is a novel potential biomarker of cardiac dysfunction in patients with chronic heart failure.
Eur. J. Heart Failure 2008; in press
Ono M, Kubota S, Fujisawa T, Sonoyama W, Kawaki H, Akiyama K, Oshima M, Nishida T, Yoshida Y, Suzuki K, Takigawa M, and Kuboki T
Promotion of hydroxyapatite-associated, stem cell-based bone regeneration by CCN2.
Cell Transplantation 2008; in press
Kubota S, and Takigawa M
Role of CCN2/CTGF/Hcs24 in Bone Growth.
Int. Rev. Cytol. 2007; 147: 1-41
Kubota S, and Takigawa M
CCN2 Molecule Page
UCSD/Nature. The Signaling Gateway. 2007; AfCS ID A003961:
URL: http://www.signaling-gateway.org/molecule/query?afcsid=A003961
Kubota S, and Takigawa M
CTGF (connective tissue growth factor).
Atlas Genet Cytogenet Oncol Haematol. 2007; CTGFID40192.
URL: http://AtlasGeneticsOncology.org/Genes/CTGFID40192ch6q23.html
Eguchi T, Kubota S, Kawata K, Mukudai Y, Ohgawara T, Miyazono K, Nakao K, Kondo S, and Takigawa M
Different transcriptional strategies of ccn2/ctgf gene induction between human chondrocytic and breast cancer cell lines.
Biochimie, 2007; 89: 278-288
Yanagita T, Kubota S, Kawata K, Kawaki H, Kondo S, Takano-Yamamoto T, Tanaka S. and Takigawa M
Expression and physiological role of CCN4/Wnt-induced secreted protein 1 mRNA splicing variants in chondrocytes
FEBS J. 2007; 274:1655-1665.
Koitabashi N, Arai M, Kogure S, Niwano K, Watanabe A, Aoki Y, Maeno T, Nishida T, Kubota S, Takigawa M, and Kurabayashi M
Increased connective tissue growth factor relative to brain natriuretic peptide as a determinant of myocardial fibrosis.
Hypertension 2007; 49:1120-1127.
Kondo S, Kubota S, Moritani N, Yosimichi G, Nishida T, Matsushita H, Matsumoto S, Kitoh T, Nakao K, Sugahara T, and Takigawa M
Hypoxic Regulation of Stability of Connective tissue growth factor/CCN2 mRNA by 3'-untranslated region interacting with a cellular protein in human chondrosarcoma cells.
Oncogene 2006; 25:1099-1110.
Shimo T, Kubota S, Eguchi T, Ibaragi S, Isowa S, Yoshioka N, Sasaki A, and Takigawa M
Pathogenic role of connective tissue growth factor (CCN2/CTGF) in osteolytic metastasis of breast cancer.
J. Bone Miner. Res. 2006; 21:1045-1059.
Yosimichi G, Kubota S, Nishida T, Kondo S, Yanagita T, Nakao K, Takano-Yamamoto T, and Takigawa M
Roles of PKC, PI3K and JNK in multiple transduction of CCN2/CTGF signals in chondrocytes.
Bone 2006; 38:853-863.
Kondo S, Tanaka N, Kubota S, Mukudai Y, Yosimichi G, Sugahara T, and Takigawa M
Novel angiogenic inhibitor DN-9693 that inhibits post-transcriptional induction of connective tissue growth factor (CTGF/CCN2) by vascular endothelial growth factor (VEGF) in human endothelial cells.
Mol. Cancer Ther. 2006; 5:129-137.