Member
H. Phillip Koeffler, MD
Division of Hematology/Oncology
Cedars-Sinai Medical Center
University of California at Los Angeles School of Medicine
Los Angeles
California, USA
Present Position
Director, Hematology/Oncology
Professor of Medicine
University of California at Los Angeles School of Medicine
Societies
American Society of Clinical Investigation
American Society Hematology
American Society of Cancer Research
International CCN Society
Awards
Holder of the Mark Goodson Chair in Oncology Research (Cedars-Sinai Medical Center)
Research Themes
I have a fairly large lab of fifteen to twenty Post Docs and Visiting Scientists, several PhD candidates, and a number of undergraduate students. My focus of interest has been CCN proteins and studying the cellular and molecular biology of cancer with special emphasis on leukemias, lymphomas, brain, breast, lung, and pancreatic cancers using cutting-edge technology such as SNP chips, microarray expression, siRNA, transduction of genes into hematopoietic cells and their injections into immunodeficient or syngenetic mice.
Selected Recent Publications
Xie D, Miller CW, O'Kelly J, Nakachi K, Sakashita A, Said JW, Gornbein J,
Koeffler HP.
Breast cancer. Cyr61 is overexpressed, estrogen-inducible, and associated with more advanced disease.
J Biol Chem. 2001 Apr 27;276(17):14187-94.
Xie D, Jauch A, Miller CW, Bartram CR, Koeffler HP.
Discovery of over-expressed genes and genetic alterations in breast cancer cells using a combination of suppression subtractive hybridization, multiplex FISH and comparative genomic hybridization.
Int J Oncol. 2002 Sep;21(3):499-507.
Xie D, Nakachi K, Wang H, Elashoff R, Koeffler HP.
Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features.
Cancer Res. 2001 Dec 15;61(24):8917-23.
Tong X, Xie D, O'Kelly J, Miller CW, Muller-Tidow C, Koeffler HP.
Cyr61, a member of CCN family, is a tumor suppressor in non-small cell lung cancer.
J Biol Chem. 2001 Dec 14;276(50):47709-14.
Xie D, Yin D, Tong X, O'Kelly J, Mori A, Miller C, Black K, Gui D, Said JW,
Koeffler HP.
Cyr61 is overexpressed in gliomas and involved in integrin-linked kinase-mediated Akt and beta-catenin-TCF/Lef signaling pathways.
Cancer Res. 2004 Mar 5;64(6):1987-96.
Xie D, Yin D, Wang HJ, Liu GT, Elashoff R, Black K, Koeffler HP.
Levels of expression of CYR61 and CTGF are prognostic for tumor progression and survival of individuals with gliomas.
Clin Cancer Res. 2004 Mar 15;10(6):2072-81.
Chien W, Kumagai T, Miller CW, Desmond JC, Frank JM, Said JW, Koeffler HP.
Cyr61 suppresses growth of human endometrial cancer cells.
J Biol Chem. 2004 Dec 17;279(51):53087-96.
Chien W, Yin D, Gui D, Mori A, Frank JM, Said J, Kusuanco D, Marchevsky A, McKenna R, Koeffler HP.
Suppression of cell proliferation and signaling transduction by connective tissue growth factor in non-small cell lung cancer cells.
Mol Cancer Res. 2006 Aug;4(8):591-8.
Gery S, Xie D, Yin D, Gabra H, Miller C, Wang H, Scott D, Yi WS, Popoviciu ML, Said JW, Koeffler HP.
Ovarian carcinomas: CCN genes are aberrantly expressed and CCN1 promotes proliferation of these cells.
Clin Cancer Res. 2005 Oct 15;11(20):7243-54.
Chen PP, Li WJ, Wang Y, Zhao S, Li DY, Feng LY, Shi XL, Koeffler HP, Tong XJ,
Xie D.
Expression of Cyr61, CTGF, and WISP-1 correlates with clinical features of lung cancer.
PLoS ONE. 2007 Jun 20;2(6):e534.
Deng YZ, Chen PP, Wang Y, Yin D, Koeffler HP, Li B, Tong XJ and Xie D.
Connective tissue growth factor is overexpressed in esophageal squamous cell carcinoma and promotes tumorigenicity through beta-catenin-T-cell factor/Lef signaling.
J Biol Chem. 2007 Dec 14;282(50):36571-81.
Mori A, Komatsu, Komtsu N, O’Kelly J, Miller CW, Legaspi r, Marchevsky, AM, McKenna RJ and Koeffler HP.
Cyr61: A new measure of lung cancer outcome.
Cancer Investigation. 2007 Dec;25(8):738-41.