Member
Ken-ichi Katsube, MD, PhD
Oral Pathology,
Graduate School of Tokyo Medical and Dental University
1-5-45 Yushima, Bunkyo-ku
Tokyo 113-8549 Japan
Tel: 81-3-5803-5452
fax: 81-3-5803-0188
Email: katsube.mpa@tmd.ac.jp
Present Position
Assistant professor
Graduate School of Tokyo Medical and Dental University
Societies
American Society for Biochemistry and Molecular Biology
Molecular Biology Society of Japan
Japanese Society of Pathology
Japanese Society of Developmental Biologists
Japanese Society of Inflammation and Regeneration (councilor)
Research Themes
Notch signal in vertebrates
CCN gene family in Developmental biology
Tumor cell invasion
Research Awards
Uehara Foundation postdoctoral research fellowship (1991)
Boursier du Gouvernement francais (Section de Science et Technologie) (1992)
Grant from Association de la Maison francojaponaise (2005)
Selected recent publications
Kishi K, Matsuda N, Kubota Y, Katsube KI, Imanishi N, Nakajima T.
Rapid, severe repigmentation of congenital melanocytic naevi after curettage and dermabrasion: histological features.
Br J Dermatol. 2007 156(6):1251-7.
Minamizato T, Sakamoto K, Liu T, Kokubo H, Katsube K, Perbal B, Nakamura S, Yamaguchi A
CCN3/NOV inhibits BMP-2-induced osteoblast differentiation by interacting with BMP and Notch signaling pathways.
Biochem Biophys Res Commun 2007 354(2):567-73.
Takahashi S, Kawashima N, Sakamoto K, Nakata A, Kameda T, Sugiyama T, Katsube K, Suda H.
Differentiation of an ameloblast-lineage cell line (ALC) is induced by Sonic hedgehog signaling.
Biochem Biophys Res Commun 2007 353 405-11
Kishi K, Katsube K, Satoh H, Imanishi N, Nakajima H, Nakajima T.
The fetal dermal but not loose fascial mesenchymal cells possess regenerative activity of dermal structure
Cell Transplantation. 2005;14(9):709-14.
Harada H, Ichimori Y, Yokohama-Tamaki T, Ohshima H, Kawano S, Katsube K, Wakisaka S.
Stratum intermedium lineage diverges from ameloblast lineage via Notch signaling.
Biochem Biophys Res Commun.2006 Feb 10;340(2):611-6.
Katsube K and Sakamoto K.
Notch in vertebrates--molecular aspects of the signal.
Int J Dev Biol. 2005; 49(2-3):369-74.
Sakamoto K, Wang SC, Katsube K, Yamaguchi A
Distinct role of EGF repeats for the Notch signaling system.
Exp. Cell Res. 23(2):123-33.2005
Shindo K, Kawashima N, Sakamoto K, Yamaguchi A, Umezawa A, Takagi M, Katsube K, Suda H.
Osteogenic differentiation of the mesenchymal progenitor cells, Kusa is suppressed by Notch signaling.
Exp Cell Res. 2003 Nov 1;290(2):370-80.
Kurokawa H, Katsube K, Podyma KA, Ikuta M, Iseki H, Nakajima M, Akashi T, Omura K, Takagi M, Yanagishita M.
Heparanase and tumor invasion patterns in human oral squamous cell carcinoma xenografts.
Cancer Sci. 2003 Mar;94(3):277-85.
Kamata T, Katsube K, Michikawa M, Yamada M, Takada S, Mizusawa H.
R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants.
Biochim Biophys Acta 2004 Jan 5;1676(1):51-62.
Brigstock DR, Goldschmeding R, Katsube KI, Lam SC, Lau LF, Lyons K, Naus C, Perbal B, Riser B, Takigawa M, Yeger H.
Proposal for a unified CCN nomenclature.
Mol Pathol. 2003 Apr;56(2):127-8.
Sakamoto K, Yamaguchi S, Ando R, Miyawaki A, Kabasawa Y, Takagi M, Li CL, Perbal B, Katsube K.
The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway.
J Biol Chem. 2002 Aug 16;277(33):29399-405.
Sakamoto K, Ohara O, Takagi M, Takeda S, Katsube K
Intracellular cell-autonomous association of Notch and its ligands: a novel mechanism of Notch signal modification.
Dev Biol. 2002 Jan 15;241(2):313-26.
Katsube K, Chuai ML, Liu YC, Kabasawa Y, Takagi M, Perbal B, Sakamoto K.
The expression of chicken NOV, a member of the CCN gene family, in early stage development.
Brain Res Gene Expr Patterns. 2001 Aug;1(1):61-5.