Member
Margarete Goppelt-Struebe, PhD
Department of Nephrology and Hypertension
University of Erlangen-Nuremberg
Loschgestrasse 8 - 91054 Erlangen,
GERMANY
Tel: 49 9131 853 9201
Fax: 49 9131 853 9202
Present Position
Professor of Molecular Pharmacology
Director of the Research Laboratories of the Medical Clinic 4, University Erlangen-Nuremberg
Societies
German Society for Pharmacology and Toxicology
German Society for Biochemistry and Molecular Biology
American Association for Biochemistry and Molecular Biology
The Biochemical Society UK
Signal Transduction Society
Research Themes
- Molecular mechanisms of anti-inflammatory and immunosuppressive drugs
- Regulation of cyclooxygenase expression in vivo and in vitro
- Cellular effects of statins as basis of an anti-fibrotic therapy
- Regulation of connective tissue growth factor (CTGF) and investigation of its role in cell physiology
- Modulation of gene expression by alterations of the cytoskeleton
Recent Publications
Gauer, S., Segitz, V., Goppelt-Struebe, M.
Aldosterone induces CTGF in mesangial cells by activation of the glucocorticoid receptor.
Nephrol. Dial. Transplant. 2007; 22:3154-3159
Cicha I., Goppelt-Struebe M., Muehlich S., Yilmaz A., Raaz D., Daniel WG., Garlichs CD.
Pharmacological inhibition of RhoA signaling prevents connective tissue growth factor induction in endothelial cells exposed to non-uniform shear stress.
Atherosclerosis. 2007; Apr 21; [Epub ahead of print]
Muehlich S., Cicha I., Garlichs CD., Krueger B., Posern G., Goppelt-Struebe M.
Actin-dependent regulation of connective tissue growth factor.
Am. J. Physiol. Cell. Physiol. 2007; 292(5):C1732-1738.
Graness, A., Poli, V., Goppelt-Struebe, M.
STAT3-independent inhibition of lysophosphatidic acid-mediated upregulation of connective tissue growth factor (CTGF) by cucurbitacin I.
Biochem. Pharmacol. 2006; 72:32-41
Graness, A., Cicha, I., Goppelt-Struebe, M.
Contribution of Src-FAK signaling to the induction of connective tissue growth factor (CTGF) in renal fibroblasts.
Kidney Int. 2006; 69: 1341-1349
Cicha I, Yilmaz A, Klein M, Raithel D, Brigstock DR, Daniel WG, GoppRelt-Struebe M, Garlichs CD.
Connective tissue growth factor is overexpressed in complicated atherosclerotic plaques and induces mononuclear cell chemotaxis in vitro.
Arterioscler. Thromb. Vasc. Biol. 2005; 25:1008-1013
Graness, A., Giehl, K., Goppelt-Struebe, M.
Differential involvement of the integrin-linked kinase (ILK) in RhoA-dependent rearrangement of F-actin fibers and induction of connective tissue growth factor (CTGF).
Cell. Signal. 2005; epub 06/05
Cicha, I., Garlichs, C.D., Daniel, W.G., Goppelt-Struebe, M.
Activated human platelets release connective tissue growth factor. Thromb. Haemost. 2004; 91:755-760
Muehlich, S., Schneider, N., Hinkelmann, F., Garlichs, C.D. Goppelt-Struebe, M.
Induction of connective tissue growth factor (CTGF) in human endothelial cells by lysophosphatidic acid, sphingosine-1-phosphate, and platelets.
Atherosclerosis 2004; 175:261-268
Cicha, I., Garlichs, C.D., Goppelt-Struebe, M.
Monitoring the cellular effects of HMG-CoA reductase inhibitors in vitro and ex vivo.
Arterioscler. Thromb. Vasc. Biol. 2004; 24:2046-205077.
Iwanciw, D., Rehm, M., Porst, M., Goppelt-Struebe, M.
Induction of connective tissue growth factor (CTGF) by angiotensin II - integration of signaling pathways.
Arterioscler. Thromb. Vasc. Biol. 2003; 23:1782-1787
Ott, C., Iwanciw, D., Graness, A., Giehl, K., Goppelt-Struebe, M.
Modulation of the expression of connective tissue growth factor by alterations of the cytoskeleton.
J. Biol. Chem. 2003; 278:44305-44311
Goppelt-Struebe, M., Hahn, A., Iwanciw, D., Banas, B.
Regulation of connective tissue growth factor gene expression in human mesangial cells: Modulation by HMG CoA reductase inhibitors (statins).
Mol. Pathol. 2001, 54:176-179
Heusinger-Ribeiro, J., Eberlein, M., Abdel Wahab, N., Goppelt-Struebe, M.
Lysophosphatidic acid-induced expression of connective tissue growth factor in human renal fibroblasts: Regulatory role of RhoA and cAMP.
J. Am. Soc. Nephrol. 2001; 12: 1853-1861
Eberlein, M., Heusinger-Ribeiro, J., Goppelt-Struebe, M.
Rho-dependent inhibition of the induction of connective tissue growth factor (CTGF) by HMG Co-A reductase inhibitors (statins).
Br. J. Pharmacol. 2001; 133:1172-1180
Hahn, A., Heusinger-Ribeiro, J., Lanz, T., Zenkel, S., Goppelt-Struebe, M.
Induction of connective tissue growth factor by activation of heptahelical receptors: Modulation by Rho proteins and the actin cytoskeleton.
J. Biol. Chem. 2000; 275:37429-37435