Member
Luc R. Desnoyers, PhD
Department of Molecular Oncology, Genentech Inc.,
1 DNA Way
South San Francisco
California 94133, USA
Tel: (650) 225-6230
Fax: (650) 225-6327
Email: desnoyer@gene.com
Present Position
Scientist in the Department of Molecular Oncology at Genentech, Inc.
Societies
American Association for Cancer Research,
American Association for the Advancement of Science
Awards
Medical Research Council of Canada Postdoctoral Fellowship Award 1994-1997
University of Montreal Award for Research presentation 1990,1991
Research Themes
My laboratory has been involved in a number of projects aiming at the characterization of novel proteins. We have identified several differentiation factors that are important for normal development but also play critical roles in cancer progression. My laboratory also works on the identification and the characterization of the major pathways that promote cancer progression. More recently we have focused our efforts on the development of anti-tumor therapies that inactivate the FGF and the CCN pathways.
Recent Publications
Patents- 1488 published applications
- 82 issued patents
Articles
Lin BC, Wang M, Blackmore C, Desnoyers LR.
Liver-specific activities of FGF19 require Klotho beta.
J Biol Chem. 2007 Sep 14;282(37):27277-84.
Desnoyers LR, Pai R, Ferrando RE, Hotzel K, Le T, Ross J, Carano R, D'Souza A, Qing J, Mohtashemi I, Ashkenazi A, French DM
Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models.
Oncogene. 2007 Jun 25; [Epub ahead of print]
Desnoyers L.
Structural basis and therapeutic implication of the interaction of CCN proteins with glycoconjugates.
Curr Pharm Des. 2004;10(31):3913-28.
French DM, Kaul RJ, D'Souza AL, Crowley CW, Bao M, Frantz GD, Filvaroff EH, Desnoyers L.
WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair.
Am J Pathol. 2004 Sep;165(3):855-67.
Desnoyers L, Simonette RA, Vandlen RL, Fendly BM
Novel non-isotopic method for the localization of receptors in tissue sections.
J Histochem Cytochem. 2001 Dec;49(12):1509-18.
Desnoyers L, Arnott D, Pennica D.
WISP-1 binds to decorin and biglycan.
J Biol Chem. 2001 Dec 14;276(50):47599-607.
Desnoyers L, Seabra MC.
Single prenyl-binding site on protein prenyl transferases.
Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12266-70.
Anant JS, Desnoyers L, Machius M, Demeler B, Hansen JC, Westover KD, Deisenhofer J, Seabra MC
Mechanism of Rab geranylgeranylation: formation of the catalytic ternary complex.
Biochemistry. 1998 Sep 8;37(36):12559-68.
Desnoyers L, Anant JS, Seabra MC
Geranylgeranylation of Rab proteins.
Biochem Soc Trans. 1996 Aug;24(3):699-703. Review. No abstract available.
Desnoyers L, Therien I, Manjunath P
Characterization of the major proteins of bovine seminal fluid by two-dimensional polyacrylamide gel electrophoresis.
Mol Reprod Dev. 1994 Apr;37(4):425-35.
Desnoyers L, Manjunath P.
Major proteins of bovine seminal fluid bind to insulin-like growth factor-II.
J Biol Chem. 1994 Feb 25;269(8):5776-80.
Manjunath P, Chandonnet L, Leblond E, Desnoyers L.
Major proteins of bovine seminal vesicles bind to spermatozoa.
Biol Reprod. 1994 Jan;50(1):27-37. Erratum in: Biol Reprod 1994 Apr;50(4):977.
Desnoyers L, Manjunath P
Interaction of a novel class of phospholipid-binding proteins of bovine seminal fluid with different affinity matrices.
Arch Biochem Biophys. 1993 Sep;305(2):341-9.
Leblond E, Desnoyers L, Manjunath P
Phosphorylcholine-binding proteins from the seminal fluids of different species share antigenic determinants with the major proteins of bovine seminal plasma.
Mol Reprod Dev. 1993 Apr;34(4):443-9.
Desnoyers L, Manjunath P.
Major proteins of bovine seminal plasma exhibit novel interactions with phospholipid.
J Biol Chem. 1992 May 15;267(14):10149-55.