Member
John Castellot, Ph.D.
Department of Anatomy and Cell Biology
Tufts University School of Medicine
136 Harrison Avenue
Boston MA 02111, USA
Tel: 1 617 636 0303
Fax: 1 617 636 0304
www.tufts.edu/sackler/cmdb/castellot-lab.htm
Present Position
Professor of Anatomy and Cell Biology
Professor of Pharmacology and Experimental Therapeutics
Director, Program in Cell, Molecular and Developmental Biology
Tufts University School of Medicine
Societies
American Society for Cell Biology
American Society for Biochemistry and Molecular Biology
American Society for Investigative Pathology
International CCN Society
Editorial Boards
Journal of Cell Communication and Signaling
Research Themes
- CCN proteins in cardiovascular disease, uterine fibroids, asthma and other smooth muscle cell-based diseases
- Regulation of smooth muscle cell proliferation
Recent Publications
Gray MR, Malmquist JA, Sullivan M, Blea M, and Castellot JJ
CCN5 Expression in Mammals. II. Adult Rodent Tissues
J. Cell Commun. Signal. 2007; 1:145-158
Malmquist JA, Gray MR, Oliveira, BE, Koch M, and Castellot JJ
CCN5 Expression in Mammals. I. Embryonic and Fetal Tissues of Human and Mouse
J. Cell Commun. Signal. 2007; 1:127-14
Gray M and Castellot JJ
Regulation of Smooth Muscle Cell Growth
Uterine Fibroids: Pathogenesis and Management. Brosens I, ed. London: Taylor and Francis, 2006; pp. 25-41.
Gray M and Castellot JJ
Biology and Pathophysiology of CCN5
The CCN Family of Proteins. Perbal B, and Takigaw M. eds. Imperial College Press, 2005; pp. 247-265.
Mason HR, Wubben M, Nowak RA, Lake AC, and Castellot JJ
The growth arrest-specific gene CCN5 is deficient in human leiomyomas and inhibits the proliferation and motility of cultured human uterine smooth muscle cells
Molec Human Reproduction 2004; 10:1-7.
Mason HR, Grove-Strawser D, Nowak RA, Rubin R, and Castellot JJ
Estrogen induces CCN5 expression in the rat uterus in vivo.
J Endocrinology 2004; 145: 976-982.
Lake AC and Castellot JJ
CCN5 modulates the antiproliferative effect of heparin and regulates cell motility in vascular smooth muscle cells
Cell Commun. Signal. 2004; 1:5-12.
Lake AC and Castellot JJ
CCN5 is a growth arrest-specific gene that inhibits vascular smooth muscle cell proliferation and motility
Amer J Pathol. 2003; 162: 219-231
Mishra-Gorur K, Singer H and Castellot JJ
The S18 ribosomal protein is a putative substrate for Ca2+/calmodulin-activated protein kinase II in vascular smooth muscle cells
J Biol Chem. 2002; 277:33527-40