Member
Paul Bornstein, MD
Department of Biochemistry
Box 357350
University of Washington
Seattle, WA 98195 - USA
Present Position
Professor of Biochemistry and Medicine
University of Washington
Societies
American Society of Biochemistry and Molecular Biology
American Society for Cell Biology
American Society for Clinical Investigation
Western Society for Clinical Research
American Chemical Society
American Rheumatism Association
Association of American Physicians
Awards and honors
Phi Beta Kappa
1954 B.A. with honors in all subjects, Cornell University
1954-1958 New York State Regents Scholarship in Medicine
1956 Wertheim Award, New York University School of Medicine
1958 Faculty Journal Club Award, New York University School of Medicine
1968-1971 Lederle Medical Faculty Award
1969-1974 Research Career Development Award
1967; 1970; 1973 Travel Awards, International Congress of Biochemistry
1974 Association of American Physicians
1975 Josiah Macy Faculty Scholar Award
1985 John Simon Guggenheim Memorial Fellowship
1989 MERIT Award, National Institute of Arthritis, Musculoskeletal and Skin Diseases
2001-2003 President, International Society for Matrix Biology
2001-2003 Vice-President and President-elect, American Society for Matrix Biology
2003- 2004 President, American Society for Matrix Biology
2004 Solomon Berson Alumni Achievement Award in Basic Science, New York University School of Medicine
Recent Publications
Yang, Z., Kyriakides, T.R., Bornstein, P.
Matricellular proteins as modulators of cell-matrix interactions: the adhesive defect in thrombospondin 2-null fibroblasts is a consequence of increased levels of matrix metalloproteinase-2.
Mol. Biol. Cell 2000;11:3353-3364.
Bornstein, P.
Thrombospondins as matricellular modulators of cell function.
J. Clin. Invest. 2001; 107:929-934.
Yang, Z., Strickland, D.K., Bornstein, P.
Extracellular MMP2 levels are regulated by the LRP scavenger receptor and thrombospondin 2.
J. Biol. Chem. 2001;276:8403-8408.
Kyriakides, T.R., Hartzell, T., Huynh, G., Bornstein, P.
Regulation of angiogenesis and matrix remodeling by localized, matrix-mediated antisense gene delivery.
Molecular Therapy 2001; 3:842-849.
Bornstein, P.,Sage, E.H.
Matricellular proteins: extracellular modulators of cell function.
Current Opin. Cell Biol. 2002;14:608-616.
Lange-Asschenfeldt, B., Weninger, W., Velasco, P., Kyriakides, T., von Andrian, U.H., Bornstein, P., Detmar, M.
Increased and prolonged inflammation and angiogenesis in delayed-type hypersensitivity reactions elicited in the skin of thrombospondin-2 deficient mice.
Blood 2002; 99:538-545.
Bornstein, P., Walsh, V., Tullis, J., Stainbrook, E., Bateman, J.,Hormuzdi, S.G.
The globular domain of the proa1(I) N-propeptide is not required for secretion, processing by procollagen N-proteinase, or fibrillogenesis of type I collagen in mice.
J. Biol. Chem. 2002; 277:2605-2613.
Agah, A., Kyriakides, T.R., Lawler, J., and Bornstein, P.
The lack of thrombospondin-1 (TSP1) dictates the course of wound healing in double-TSP1/TSP2-null mice.
Am. J.Path. 2002; 161:831-839.
Kyriakides, T.R., Rojnuckarin, P., Reidy, M.A., Hankenson, K.D., Papayannopoulou, T., Kaushansky, K., Bornstein, P.
Megakaryocytes require thrombospondin 2 for normal platelet formation and function.
Blood 2003; 101:3915-3923.
Bornstein, P., Agah, A., Kyriakides, T.R.
The role of thrombospondins 1 and 2 in the regulation of cell-matrix interactions, collagen fibril formation, and the response to injury.
Int. J. Biochem. Cell Biol. 2004;36:1115-1125.
Rahkonen, O., Su, M., Hakovirta, H., Koskivirta, I., Hormuzdi, S.G., Vuorio, E., Bornstein, P.,Penttinen, R.
Mice with a deletion in the first intron of the Col1a1 gene develop age-dependent aortic dissection and rupture.
Circ. Res. 2004; 94:83-90.
Kyriakides, T.R., Foster, M.J., Keeney, G.E., Tsai, A., Giachelli, C.M., Clark-Lewis, I., Rollins, B.J.,Bornstein, P.
The CC chemokine ligand, CCL2/MCP1, participates in macrophage fusion and foreign body giant cell formation.
Am. J. Pathol. 2004;165: 2157-2166,.
Christopherson, K,S., Ullian, E.M., Stokes, C.C.A., Mulloowney, C.E., Agah, A., Lawler, J., Mosher, D.F., Bornstein, P., Barres, B.A.
Thrombospondins are astrocyte proteins that promote CNS synaptogenesis.
Cell 2005; 120: 421-433.
Hankenson, K.D., Hormuzdi, S.G., Meganck, J.A.,Bornstein, P.
Mice with a disruption of the thrombospondin 3 gene differ in geometric and biochemical properties of bone and have accelerated development of the femoral head.
Mol. Cell. Biol. 2005; 25: 5599-5606.
Agah, A., Kyriakides, T.R.,Bornstein, P.
Proteolysis of cell-surface tissue transglutaminase by matrix metalloproteinase-2 contributes to the adhesive defect and matrix abnormalities in thrombospondin-2-null fibroblasts and mice.
Am. J. Path. 2005; 167: 81-88.
Chen, J., Somanath, P.R., Razorenova, O., Chen, W.S., Hay, N., Bornstein, P., Byzova, T.
Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo.
Nature Medicine. 2005; 11:1188-1196.
Oganesian, A., Au, S., Horst, J.A., Holzhausen, L. C., Macy, A. J., Pace, J. M., and Bornstein, P.
The NH2-Terminal propeptide of type I procollagen acts intracellularly to modulate cell function.
J. Biol. Chem. 2006; 281: 3807-3815.
Kopp, H-G, Hooper, A.T., Broekman, M.J., Avecilla, S.T., Petit, I., Luo, M., Milde, T., Ramos, C.A. Zhang, H., Jopp, T., Bornstein, P., Lawler, J., Jin, D.K., Marcus, A.J.,Rafii, S
Thrombospondins deployed by thrombopoetic cells determine angiogenic switch and extent of revascularization.
J. Clin. Invest. 2006; 116:3277-3291.
Lamy, L., Foussat, A., Brown, E.J., Bornstein, P., Ticchioni, M.,Bernard, A.
Interactions between CD47 and thrombospondin reduce inflammation.
J. Immunol. 2007; 178: 5930-5939