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Ulf Smith

Ulf Smith, M.D., Ph.D., FRCP.
Department of Molecular and Clinical Medicine
University of Gothenburg
Sahlgrenska University Hospital
SE-413 45 Gothenburg, SWEDEN
Tel: (+46) 31-3421104
Fax: (+46) 31-829138
ulf.smith@medic.gu.se
http://www.gu.se
http://www.sahlgrenska.gu.se/lundberglab

Present Position

  • Professor of Medicine, University of Gothenburg
  • Head of the Lundberg Laboratory for Diabetes Research

Societies

  • European Association for the Study of Diabetes (EASD)
  • American Diabetes Association
  • American Society of Biochemistry and Molecular Biology
  • The Alliance for Biomedical Research in Europe
  • International CCN Society

Editorial Boards

  • Journal of Cell Communication and Signaling 2014- present
  • Journal of Internal Medicine, 1998– present
  • Assoc. Editor, Diabetologia, 2007-2011

Awards

  • Jühling Award, German Diabetes Center, 2008
  • Albert E. Renold Award, EASD, 2008
  • Novo Nordisk Award in Diabetes Research, 2007
  • The Lundberg Award, 2005
  • The Meilahti Award, 1997
  • Fogarty Scholar, National Institutes of Health, 1996-2000

Research Themes

  • Mechanisms of insulin signaling and action
  • Regulation of canonical Wnt signaling and cell differentiation
  • CCN5 in cell lineage commitment and differentiation

Selected Publications

  • Gustafson B, Hammarstedt A, Hedjazifar S and Smith U
    Restricted Adipogenesis in Hypertrophic Obesity – role of WISP2, WNT and BMP4.
    Diabetes 62:2997-3004, 2013.
  • Hammarstedt A, Hedjazifar S, Jenndahl L, Gogg S, Grünberg J, Gustafson B, Klimcakova E, Stich V, Langin D, Laakso M and Smith U
    WISP2 Regulates Preadipocyte Commitment and PPARγ Activation by BMP4.
    Proc Natl Acad Sci 110:2563-2568, 2013.
  • Gustafson B and Smith U
    Activation of canonical Wingless-type MMTV integration site family (WNT) signaling in mature adipocytes increases beta-catenin levels and leads to cell dedifferentiation and insulin resistance.
    J Biol Chem 285:14031-14041, 2010.
  • Graham TE, Yang Q, Bluher M, Hammarstedt A, Ciaraldi TP, Henry RR, Wason CJ, Oberbach A, Jansson P-A, Smith U and Kahn BB
    Retinol binding protein 4 and insulin resistance in lean, obese, and diabetic subjects.
    N Engl J Med 354:2552-2563, 2006.
  • Gustafson B and Smith U
    Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes.
    J Biol Chem. 281:9507-9516, 2006.
  • Rotter V, Nagaev I and Smith U
    Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and Tumor Necrosis Factor-, overexpressed in human fat cells from insulin-resistant subjects.
    J Biol Chem. 278:45777-45784, 2003.
  • Rondinone C, Carvalho E, Rahn T, Manganiello V, Degerman E and Smith U
    Phosphorylation of PDE3B by Phosphatidylinositol 3-Kinase Associated with the Insulin Receptor.
    J Biol Chem 275:10093-10098, 2000.
  • Gogg S and Smith U
    Epidermal growth factor (EGF) and TGF mimic the effects of insulin in human fat cells but exhibit different signaling mechanisms.
    J Biol Chem 277:36045-36051, 2002.
  • Carvalho E, Jansson P-A, Axelsen M, Eriksson J, Huang X, Groop L, Rondinone C, Sjöström L and Smith U
    Low cellular IRS 1 gene and protein expression predict insulin resistance and NIDDM.
    FASEB J 13:2173-2178, 1999.
  • Rondinone CM, Wang L-M, Lönnroth P, Wesslau C, Pierce JH and Smith U
    Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus.
    Proc Natl Acad Sci 94:4171-4175, 1997.