The International CCN Society

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Roel Goldschmeding

Roel Goldschmeding, M.D., Ph.D.
Department of Pathology (H04.312)
UMC Utrecht,
Heidelberglaan 100 - 3584CX Utrecht
THE NETHERLANDS
Tel: 31 887 55 65 59
Fax: 31 254 49 90
r.goldschmeding@umcutrecht.nl
http://pathologyutrecht.nl

Present Position

  • Professor of Translational Pathology,  Head of Pathology Research, Department of Pathology, University Medical Center Utrecht

Societies

  • International CCN Society 
  • International Society of Nephrology
  • Renal Pathology Society
  • American Society of Nephrology
  • European Renal Association/European Dialysis and Transplant Association
  • Dutch Federation of Nephrology
  • Dutch Pathology Society
  • Dutch Immunology Society
  • Dutch Society for the Study of Diabetes

Editorial Boards

  • Nephrology Dialysis Transplantation
  • Journal of Cell Communication and Signaling

Research Themes

  • Renal and Cardiovascular remodeling, fibrosis and regeneration
  • The roles of CCN-2 in tissue response to injury
  • Modulation of BMP-signaling activity by CCN-2 and other proteins
  • Renal Pathology

Recent Publications

  • Leeuwis JW, Nguyen TQ, Chuva de Sousa Lopes SM, Van der Giezen DM, Van der Ven K, Rouw PJ, Offerhaus GJ, Mummery CL, Goldschmeding R. Visualization of Smad1/5/8-mediated transcriptional activity identifies podocytes and collecting ducts as major targets of Bone Morphogenetic Protein signalling in healthy and diseased kidneys. J Pathol. 2011; in press.
  • Dendooven A, van Oostrom O, Van der Giezen DM, Leeuwis JW, Snijckers C, Joles JA, Robertson EJ, Verhaar MC, Nguyen TQ, Goldschmeding R. Loss of endogenous bone morphogenetic protein-6 (BMP-6) aggravates renal fibrosis. Am J Pathol. 2011; in press.
  • Ito Y, Aten J, Nguyen TQ, Joles JA, Matsuo S, Weening JJ, Goldschmeding R. Involvement of CCN-2 (connective tissue growth factor) in human and experimental hypertensive nephrosclerosis. Nephron Exp Nephrol. 2011;117(1):e9-e20. 
  • Leeuwis JW, Nguyen TQ, Theunissen MG, Peeters W, Goldschmeding R, Pasterkamp G, Vink A. CCN-2 (connective tissue growth factor) is associated with a stable atherosclerotic plaque phenotype and is involved in plaque stabilization after stroke. Stroke. 2010 Dec;41(12):2979-81. 
  • Westerweel PE, van Velthoven CT, Nguyen TQ, den Ouden K, de Kleijn DP, Goumans MJ, Goldschmeding R, Verhaar MC. Modulation of TGF-?/BMP-6 expression and increased levels of circulating smooth muscle progenitor cells in a type I diabetes mouse model. Cardiovasc Diabetol. 2010 Sep 21;9:55. 
  • Leeuwis JW, Nguyen TQ, Dendooven A, Kok RJ, Goldschmeding R. Targeting podocyte-associated diseases. Adv Drug Deliv Rev. 2010 Nov 30;62(14):1325-36.
  • Ito Y, Goldschmeding R, Kasuga H, Claessen N, Nakayama M, Yuzawa Y, Sawai A, Matsuo S, Weening JJ, Aten J. Expression patterns of CCN-2 (connective tissue growth factor) and of TGF-beta isoforms during glomerular injury recapitulate glomerulogenesis. Am J Physiol Renal Physiol. 2010 Sep;299(3):F545-58.
  • Carew RM, Sadagurski M, Goldschmeding R, Martin F, White MF, Brazil DP. Deletion of Irs2 causes reduced kidney size in mice: role for inhibition of GSK3beta? BMC Dev Biol. 2010 Jul 6;10:73. 
  • Gerritsen KG, Peters HP, Nguyen TQ, Koeners MP, Wetzels JF, Joles JA, Christensen EI, Verroust PJ, Li D, Oliver N, Xu L, Kok RJ, Goldschmeding R. Renal proximal tubular dysfunction is a major determinant of urinary CCN-2 (connective tissue growth factor) excretion. Am J Physiol Renal Physiol. 2010 Jun;298(6):F1457-64. 
  • Tanaka M, Asada M, Higashi AY, Nakamura J, Oguchi A, Tomita M, Yamada S, Asada N, Takase M, Okuda T, Kawachi H, Economides AN, Robertson E, Takahashi S, Sakurai T, Goldschmeding R, Muso E, Fukatsu A, Kita T, Yanagita M. Loss of the BMP antagonist USAG-1 ameliorates disease in a mouse model of the progressive hereditary kidney disease Alport syndrome. J Clin Invest. 2010 Mar 1;120(3):768-77. 
  • Mizutani M, Ito Y, Mizuno M, Nishimura H, Suzuki Y, Hattori R, Matsukawa Y, Imai M, Oliver N, Goldschmeding R, Aten J, Krediet RT, Yuzawa Y, Matsuo S. Connective tissue growth factor (CTGF/CCN2) is increased in peritoneal dialysis patients with high peritoneal solute transport rate. Am J Physiol Renal Physiol. 2010 Mar;298(3):F721-33. 
  • Veerasamy M, Nguyen TQ, Motazed R, Pearson AL, Goldschmeding R, Dockrell ME. Differential regulation of E-cadherin and alpha-smooth muscle actin by BMP 7 in human renal proximal tubule epithelial cells and its implication in renal fibrosis. Am J Physiol Renal Physiol. 2009 Nov;297(5):F1238-48.
  • Turk T, Leeuwis JW, Gray J, Torti SV, Lyons KM, Nguyen TQ, Goldschmeding R. BMP signaling and podocyte markers are decreased in human diabetic nephropathy in association with CTGF overexpression. J Histochem Cytochem. 2009 Jul;57(7):623-31.
  • Roxburgh SA, Kattla JJ, Curran SP, O'Meara YM, Pollock CA, Goldschmeding R, Godson C, Martin F, Brazil DP. Allelic depletion of grem1 attenuates diabetic kidney disease. Diabetes. 2009 Jul;58(7):1641-50.
  • Daniels A, van Bilsen M, Goldschmeding R, van der Vusse GJ, van Nieuwenhoven FA.  CCN-2 (connective tissue growth factor) and cardiac fibrosis. Acta Physiol (Oxf). 2009 Mar;195(3):321-38.
  • Fretz MM, Dolman ME, Lacombe M, Prakash J, Nguyen TQ, Goldschmeding R, Pato J, Storm G, Hennink WE, Kok RJ. Intervention in growth factor activated signalling pathways by renally targeted kinase inhibitors. J Control Release. 2008 Dec 18;132(3):200-7.
  • Kuiper EJ, van Zijderveld R, Roestenberg P, Lyons KM, Goldschmeding R, Klaassen I, Van Noorden CJ, Schlingemann RO. CCN-2 (connective tissue growth factor) is necessary for retinal capillary basal lamina thickening in diabetic mice. J Histochem Cytochem. 2008 Aug;56(8):785-92.  
  • Kuiper EJ, Van Nieuwenhoven FA, de Smet MD, van Meurs JC, Tanck MW, Oliver N, Klaassen I, Van Noorden CJ, Goldschmeding R, Schlingemann RO. The angio-fibrotic switch of VEGF and CCN-2/CTGF in proliferative diabetic retinopathy. PLoS One. 2008 Jul 16;3(7):e2675.
  • Nguyen TQ, Roestenberg P, van Nieuwenhoven FA, Bovenschen N, Li Z, Xu L, Oliver N, Aten J, Joles JA, Vial C, Brandan E, Lyons KM, Goldschmeding R. CCN-2/CTGF inhibits BMP-7 signaling in diabetic nephropathy. J Am Soc Nephrol. 2008 Nov;19(11):2098-107.
  • Nguyen TQ, Tarnow L, Jorsal A, Oliver N, Roestenberg P, Ito Y, Parving HH, Rossing P, van Nieuwenhoven FA, Goldschmeding R. Plasma CCN-2 (connective tissue growth factor) is an independent predictor of end-stage renal disease and mortality in type 1 diabetic nephropathy. Diabetes Care. 2008 Jun;31(6):1177-82.
  • Nguyen TQ, Goldschmeding R.
    Bone Morphogenetic Protein-7 and Connective Tissue Growth Factor: Novel Targets for Treatment of Renal Fibrosis? 
    Pharm Res. 2008 Feb 12; [Epub ahead of print]
  • Kuiper EJ, Roestenberg P, Ehlken C, Lambert V, van Treslong-de Groot HB, Lyons KM, Agostini HJ, Rakic JM, Klaassen I, Van Noorden CJ, Goldschmeding R, Schlingemann RO.
    Angiogenesis is not impaired in connective tissue growth factor (CTGF) knock-out mice.
    J Histochem Cytochem. 2007 Nov;55(11):1139-47
  • Kuiper EJ, de Smet MD, van Meurs JC, Tan HS, Tanck MW, Oliver N, van Nieuwenhoven FA, Goldschmeding R, Schlingemann RO.
    Association of connective tissue growth factor with fibrosis in vitreoretinal disorders in the human eye.
    Arch Ophthalmol. 2006 Oct;124(10):1457-62.
  • Wetzel P, Haag J, Câmpean V, Goldschmeding R, Atalla A, Amann K, Aigner T.
    Bone morphogenetic protein-7 expression and activity in the human adult normal kidney is predominantly localized to the distal nephron.
    Kidney Int. 2006 Aug;70(4):717-23.
  • Nguyen TQ, Chon H, van Nieuwenhoven FA, Braam B, Verhaar MC, Goldschmeding R.
    Myofibroblast progenitor cells are increased in number in patients with type 1 diabetes and express less bone morphogenetic protein 6: a novel clue to adverse tissue remodelling?
    Diabetologia. 2006 May;49(5):1039-48
  • Roestenberg P, van Nieuwenhoven FA, Joles JA, Trischberger C, Martens PP, Oliver N, Aten J, Höppener JW, Goldschmeding R.
    Temporal expression profile and distribution pattern indicate a role of connective tissue growth factor (CTGF/CCN-2) in diabetic nephropathy in mice.
    Am J Physiol Renal Physiol. 2006 Jun;290(6):F1344-54
  • Nguyen TQ, Tarnow L, Andersen S, Hovind P, Parving HH, Goldschmeding R, van Nieuwenhoven FA.
    Urinary connective tissue growth factor excretion correlates with clinical markers of renal disease in a large population of type 1 diabetic patients with diabetic nephropathy.
    Diabetes Care. 2006 Jan;29(1):83-8.
  • Andersen S, van Nieuwenhoven FA, Tarnow L, Rossing P, Rossing K, Wieten L, Goldschmeding R, Parving HH.
    Reduction of urinary connective tissue growth factor by Losartan in type 1 patients with diabetic nephropathy.
    Kidney Int. 2005 Jun;67(6):2325-9.
  • van Nieuwenhoven FA, Jensen LJ, Flyvbjerg A, Goldschmeding R.
    Imbalance of growth factor signalling in diabetic kidney disease: is connective tissue growth factor (CTGF, CCN2) the perfect intervention point?
    Nephrol Dial Transplant. 2005 Jan;20(1):6-10
  • Chuva de Sousa Lopes SM, Feijen A, Korving J, Korchynskyi O, Larsson J, Karlsson S, ten Dijke P, Lyons KM, Goldschmeding R, Doevendans P, Mummery CL.
    Connective tissue growth factor expression and Smad signaling during mouse heart development and myocardial infarction.
    Dev Dyn. 2004 Nov;231(3):542-50.
  • Kuiper EJ, Witmer AN, Klaassen I, Oliver N, Goldschmeding R, Schlingemann RO.
    Differential expression of connective tissue growth factor in microglia and pericytes in the human diabetic retina.
    Br J Ophthalmol. 2004 Aug;88(8):1082-7.
  • Roestenberg P, van Nieuwenhoven FA, Wieten L, Boer P, Diekman T, Tiller AM, Wiersinga WM, Oliver N, Usinger W, Weitz S, Schlingemann RO, Goldschmeding R.
    Connective tissue growth factor is increased in plasma of type 1 diabetic patients with nephropathy.
    Diabetes Care. 2004 May;27(5):1164-70.
  • Lam S, van der Geest RN, Verhagen NA, van Nieuwenhoven FA, Blom IE, Aten J, Goldschmeding R, Daha MR, van Kooten C.
    Connective tissue growth factor and igf-I are produced by human renal fibroblast and cooperate in the induction of collagen production by high glucose.
    Diabetes. 2003 Dec;52(12):2975-83
  • Brigstock DR, Goldschmeding R, Katsube KI, Lam SC, Lau LF, Lyons K, Naus C, Perbal B, Riser B, Takigawa M, Yeger H.
    Proposal for a unified CCN nomenclature.
    Mol Pathol. 2003 Apr;56(2):127-8.
  • Blom IE, Goldschmeding R, Leask A.
    Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy?
    Matrix Biol. 2002 Oct;21(6):473-82.
  • Chen Y, Blom IE, Sa S, Goldschmeding R, Abraham DJ, Leask A.
    CTGF expression in mesangial cells: involvement of SMADs, MAP kinase, and PKC.
    Kidney Int. 2002 Oct;62(4):1149-59.
  • Keil A, Blom IE, Goldschmeding R, Rupprecht HD.
    Nitric oxide down-regulates connective tissue growth factor in rat mesangial cells.
    Kidney Int. 2002 Aug;62(2):401-11.
  • Blom IE, van Dijk AJ, Wieten L, Duran K, Ito Y, Kleij L, deNichilo M, Rabelink TJ, Weening JJ, Aten J, Goldschmeding R.
    In vitro evidence for differential involvement of CTGF, TGFbeta, and PDGF-BB in mesangial response to injury.
    Nephrol Dial Transplant. 2001 Jun;16(6):1139-48.
  • Blom IE, van Dijk AJ, de Weger RA, Tilanus MG, Goldschmeding R.
    Identification of human ccn2 (connective tissue growth factor) promoter polymorphisms.
    Mol Pathol. 2001 Jun;54(3):192-6.
  • Ito Y, Goldschmeding R, Bende R, Claessen N, Chand M, Kleij L, Rabelink T, Weening J, Aten J.
    Kinetics of connective tissue growth factor expression during experimental proliferative glomerulonephritis.
    J Am Soc Nephrol. 2001 Mar;12(3):472-84.
  • Goldschmeding R, Aten J, Ito Y, Blom I, Rabelink T, Weening JJ.
    Connective tissue growth factor: just another factor in renal fibrosis?
    Nephrol Dial Transplant. 2000 Mar;15(3):296-9
  • Roose J, Huls G, van Beest M, Moerer P, van der Horn K, Goldschmeding R, Logtenberg T, Clevers H.
    Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1.
    Science. 1999 Sep 17;285(5435):1923-6.
  • Ito Y, Aten J, Bende RJ, Oemar BS, Rabelink TJ, Weening JJ, Goldschmeding R.
    Expression of connective tissue growth factor in human renal fibrosis.
    Kidney Int. 1998 Apr;53(4):853-61.
    Immunol Today. 1991 Feb;12(2):61-4
  • Goldschmeding R, van der Schoot CE, ten Bokkel Huinink D, Hack CE, van den, Ende ME, Kallenberg CG, von dem Borne AE.
    Wegener's granulomatosis autoantibodies identify a novel diisopropylfluorophosphate-binding protein in the lysosomes of normal human neutrophils.
    J Clin Invest. 1989 Nov;84(5):1577-87.