The International CCN Society

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Philip C. Trackman

Philip C. Trackman, Ph.D.
Department of Molecular and Cell Biology
Henry M. Goldman School of Dental Medicine
Boston University
700 Albany Street; W-201
Boston, MA 02118 USA
Tel: ((617) 638-4076

Present Positions

  • Professor and Director of Graduate Programs,
    Boston University Henry M. Goldman School of Dental Medicine,
    Department of Molecular and Cell Biology
  • Research Assistant Professor,
    Boston University School of Medicine,
    Department of Biochemistry


  • International CCN Society
  • American Society of Matrix Biology
  • American Society of Bone and Mineral Research
  • American Society of Biochemistry and Molecular Biology
  • American Diabetes Association
  • International Association for Dental Research
  • American Chemical Society

Editorial Boards

  • Academic Editor, PLoS One, 2012 – present
  • Editorial Board, Journal of Dental Research (2000-2005)


  • American Chemical Society “Outstanding Senior Award”
  • Predoctoral NIH Traineeship, Boston University School of Medicine
  • American Cancer Society Postdoctoral Fellowship, Brandeis University

Research Interests

  • Biosynthesis of the extracellular matrix
  • Understanding extracellular matrix perturbations in pathology in order to develop possible novel therapeutic strategies
  • Tissue-specific regulation of CCN2 and mechanisms of CCN2-induced fibrosis
  • Biology and biochemistry of lysyl oxidases and extracellular matrix maturation
  • Mechanisms of the tumor suppressor activity of lysyl oxidase

Selected Recent Publications

  • Khosravi, R., Sodek, K.L., Faibish, M., Trackman, P.C. (2014)
    Collagen advanced glycation inhibits its Discoidin Domain Receptor 2 (DDR2)-mediated induction of lysyl oxidase in osteoblasts.
    Bone 58, 33 – 41.
  • Bahammam, M., Black, S.A., Jr., Sume, S.S., Assaggaf, M.A., Faibish, M., Trackman, P.C. (2013)
    Requirement for active glycogen synthase kinase 3β in TGF-β1 upregulation of connective tissue growth factor (CCN2/CTGF) levels in human gingival fibroblasts.
    Am. J. Physiol. Cell Physiol. 305, C581 – 90.
  • Beerlage, C., Greb, J., Kretschmer, D., Assaggaf, M., Trackman, P.C., Hansmann, M.L., Bonin, M., Eble, J.A., Peschel, A., Kempf, V.A. (2013)
    Hypoxia-inducible factor 1-regulated lysyl oxidase is involved in Staphlococcus aureus abscess formation.
    Infect. Immun. 81, 2562 – 73.
  • Eliades, A., Papadantonakis, N., Matsuura, S., Mi, R., Bais, M.V., Trackman, P.C., Ravid, K. (2013)
    Megakaryocyte polyploidy is inhibited by lysyl oxidase propeptide.
    Cell Cycle 12, 1242 – 50.
  • Yu, Z., Sato, S., Trackman, P. C., Kirsch, K. H., and Sonenshein, G. E. (2012)
    Blimp1 activation by AP-1 in human lung cancer cell promotes a migratory phenotype and is inhibited by the lysyl oxidase propeptide.
    PLoS One 7, e33287.
  • Bais, M. V., Nugent, M. A., Stephens, D. N., Sume, S. S., Kirsch, K. H., Sonenshein, G. E. and Trackman, P. C. (2012)
    Recombinant lysyl oxidase propeptide protein inhibits growth and promotes apoptosis of pre-existing murine breast cancer xenografts.
    PLoS One 7, e3188.
  • Sanchez-Morgan, N., Kirsch,K. H., Trackman, P.C., Soneneshein, G. E. (2011)
    The lysyl oxidase propeptide interacts with the receptor-type protein tyrosine phosphatase kappa and inhibits beta-catenin transcriptional activity in lung cancer cells.
    Mol. Cell Biol. 31, 3286 – 3297.
  • Elliades, A., Papadantonakis, N., Bhupatiraju, A., Burridge, K. A., Johnston-Cox, H.A., Migliaccio, A. R., Crispino, J. D., Lucero, H. A., Trackman, P. C., Ravid, K. (2011)
    Control of megakaryocyte expansion and bone marrow fibrosis by lysyl oxidase.
    J. Biol. Chem. 286, 27630 – 27638.
  • Sato, S., Trackman, P. C., Maki, J. M., Myllyarju, J., Kirsch, K. H., Sonenshein, G.E. (2011)
    The Ras signaling inhibitor LOX-PP interacts with Hsp70 and c-Raf to reduce Erk activation and transformed phenotype of breast cancer cells.
    Mol. Cell Biol. 31, 2683 – 2695.
  • Chen, H., Koupenova, M., Yang, D. Sume, S.S., Trackman, P.C., Ravid, K. (2011)
    Regulation of MMP-9 expression by the A2b adenosine receptor and its dependency on TNF-α signaling.
    Exp. Hematol. 39, 525-30.
  • Kantarci, A., Nseir, Z., Kim, Y. –S., Sume, S. S., Trackman, P.C. (2011)
    Loss of basement membrane integrity in human gingival overgrowth.
    J. Dent. Res. 90, 887 – 893.
  • Iftikhar, M., Hurtado, P., Bais, M.V., Wigner, N., Stephens, D.N., Gerstenfeld, L.C., Trackman, P.C. (2011)
    Lysyl oxidase-like-2 (LOXL2) is a major isoform in chondrocytes and is critically required for differentiation.
    J. Biol. Chem. 286, 909-918.
  • Chronopoulos, A., Tang, A., Beglova, E., Trackman, P.C., Roy, S. (2010)
    High glucose increases lysyl oxidase expression and activity in retinal endothelial cells: mechanism for compromised extracellular matrix barrier function.
    Diabetes 59, 3159 – 3166.
  • Min, C., Zhao, Y., Romagnoli, M., Trackman, P.C., Sonenshein, G.E., Kirsch, K.H. (2010)
    Lysyl oxidase propeptide sensitizes pancreatic and breast cancer cells to doxorubicin-induced apoptosis.
    J. Cell Biochem. 111, 1160 – 1168.
  • Grimsby, J.L., Lucero, H.A., Trackman, P.C., Ravid, K., Kagan, H.M. (2010)
    Role of lysyl oxidase propeptide in secretioin and enzyme activity.
    J. Cell Biochem. 111, 1231 – 1243.
  • Sume, S. –S., Kantarci, A., Lee, A., Hasturk, H., Trackman, P.C. (2010)
    Epithelial to mesenchymal transition in gingival overgrowth.
    Am. J. Pathol. 177, 208 – 218.
  • Vora, S.R., Guo, Y., Stephens, D.N., Salih, E., Vu, E.D., Kirsch, K.H., Sonenshein, G.E., Trackman, P.C. (2010)
    Characterization of recombinant lysyl oxidase propeptide.
    Biochemistry 49, 2962 – 72.
  • Vora, S.R., Palamakumbura, A.H., Mitsi, M., Guo, Y., Pischon, N., Nugent, M.A., Trackman, P.C. (2010)
    Lysyl oxidase propeptide inhibits FGF-2-induced signaling and proliferation of osteoblasts.
    J. Biol. Chem. 285, 7384 – 93.
  • Black, S.A. Jr., Palamakumbura, A.H., Stan, M., and Trackman, P.C. (2007)
    Tissue specific mechanisms for CCN2/CTGF persistence in fibrotic gingiva: interactions between cAMP and MAPK signaling pathways, and prostaglandin EP2-EP3 receptor mediated activation of the c-JUN N-terminal kinase.
    J. Biol. Chem. 282, 15416 – 29.
  • Black, S.A. Jr., Trackman, P.C. (2008)
    Transforming growth factor-beta1 (TGF-β1) stimulates connective tissue growth factor (CCN2/CTGF) expression in human gingival fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent mechanism: statins with forskolin block TGF-β1-induced CCN2/CTGF expression.
    J. Biol. Chem. 283, 10835-47.
  • Kantarci, A., Black, S. A., Xydas, C., Murawel, P., Uchida, Y., Atilla, G., Uzel, M.I., Firatli, E., Hasturk, H., Van Dyke, T. E. and Trackman, P. C. (2006)
    Epithelial and connective tissue cell CTGF/CCN2 expression in gingival fibrosis
    J. Pathol 210, 59-66
  • Heng, E. C., Huang, Y., Black, S. A., Jr., and Trackman, P. C. (2006)
    CCN2, connective tissue growth factor, stimulates collagen deposition by gingival fibroblasts via module 3 and alpha-6 and beta-1 integrins.
    J. Cell Biochem. 98, 409 – 20.
  • Uzel, M.I., Kantarci, A., Hong, H., Uygur, C., Sheff, M., Firalti, E., Trackman, P.C. (2001)
    Connective Tissue Growth Factor in Drug-Induced Gingival Overgrowth.
    J. Periodontol. 72, 921-931.
  • Hong, H. –H., Uzel, M. I., Duan, C., Sheff, M. C., & Trackman, P. C. (1999)
    Regulation of lysyl oxidase, collagen and connective tissue growth factor by TGFβ1 and detection in human gingiva.
    Laboratory Investigation 79, 1655 - 1667.