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Ken-ichi Katsube

 

Ken-ichi Katsube, MD, PhD
Oral Pathology
Graduate School of Tokyo Medical and Dental University
1-5-45 Yushima, Bunkyo-ku
Tokyo 113-8549 Japan
Tel: 81-3-5803-5452
fax: 81-3-5803-0188
mailto:ken-tmd@umin.ac.jp

Present Position

  • Assistant professor,
    Graduate School of Tokyo Medical and Dental University

Societies

  • American Society for Biochemistry and Molecular Biology
  • Molecular Biology Society of Japan
  • Japanese Society of Pathology
  • Japanese Society of Developmental Biologists
  • Japanese Society of Inflammation and Regeneration (councilor)

Research Themes

  • Notch signal in vertebrates
  • CCN gene family in Developmental biology
  • Tumor cell invasion

Research Awards

  • Uehara Foundation postdoctoral research fellowship (1991)
  • Boursier du Gouvernement francais (Section de Science et Technologie) (1992)
  • Grant from Association de la Maison francojaponaise (2005)

Selected recent publications

  • Tanabe H, Takayama I, Nishiyama T, Shimazaki M, Kii I, Li M, Amizuka N, Katsube K, Kudo A
    Periostin associates with Notch1 precursor to maintain Notch1 expression under a stress condition in mouse cells.
    Plos One 2010 Aug 18;5(8):e12234
  • Katsube K, Ichikawa S, Katsuki Y, Kihara T, Terai M. Tamura Y, Lau LF, Takeda S, Umezawa A,Sakamoto K, Yamaguchi A.
    CCN3 and bone marrow cells
    J Cell Comm Signal. 3(2):135-45 2009
  • Katsuki Y, Sakamoto K, Minamizato T, Makino H, Umezawa A, Ikeda MA, Perbal B, Amagasa T, Yamaguchi A, Katsube K.
    Inhibitory effect of CT domain of CCN3/NOV on proliferation and differentiation of osteogenic mesenchymal stem cells, Kusa-A1.
    Biochem Biophys Res Comm 368(3):808-14. 2008
  • Minamizato T, Sakamoto K, Liu T, Kokubo H, Katsube K, Perbal B, Nakamura S, Yamaguchi A
    CCN3/NOV inhibits BMP-2-induced osteoblast differentiation by interacting with BMP and Notch signaling pathways.
    Biochem Biophys Res Commun 2007 354(2):567-73..
  • Katsube K and Sakamoto K.
    Notch in vertebrates--molecular aspects of the signal.
    Int J Dev Biol. 2005; 49(2-3):369-74.
  • Shindo K, Kawashima N, Sakamoto K, Yamaguchi A, Umezawa A, Takagi M, Katsube K, Suda H.
    Osteogenic differentiation of the mesenchymal progenitor cells, Kusa is suppressed by Notch signaling.
    Exp Cell Res. 2003 Nov 1;290(2):370-80.
  • Kamata T, Katsube K, Michikawa M, Yamada M, Takada S, Mizusawa H.
    R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants.
    Biochim Biophys Acta 2004 Jan 5;1676(1):51-62.
  • Sakamoto K, Yamaguchi S, Andoh R, Miyawaki A, Kabasawa Y, Takagi M, Li CL, Perbal B, Katsube K
    The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway.
    J Biol Chem. 2002 Aug 16;277(33):29399-405.
  • Sakamoto K, Ohara O, Takagi M, Takeda S, Katsube K
    Intracellular cell-autonomous association of Notch and its ligands: a novel mechanism of Notch signal modification.
    Dev Biol. 2002 Jan 15;241(2):313-26.
  • Katsube K, Chuai ML, Liu YC, Kabasawa Y, Takagi M, Perbal B, Sakamoto K.
    The expression of chicken NOV, a member of the CCN gene family, in early stage development.
    Brain Res Gene Expr Patterns. 2001 Aug;1(1):61-5.