The International CCN Society

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John Castellot

 

John Castellot, Ph.D.
Department of Anatomy and Cell Biology
Tufts University School of Medicine
136 Harrison Avenue
Boston MA 02111, USA
Tel: 1 617 636 0303
Fax: 1 617 636 0304
john.castellot@tufts.edu
www.tufts.edu/sackler/cmdb/castellot-lab.htm

Present Position

  • Professor of Anatomy and Cell Biology
    Professor of Pharmacology and Experimental Therapeutics
    Director, Program in Cell, Molecular and Developmental Biology
    Tufts University School of Medicine

Societies

  • American Society for Cell Biology
  • American Society for Biochemistry and Molecular Biology
  • American Society for Investigative Pathology
  • International CCN Society

Editorial Boards

  • Journal of Cell Communication and Signaling

Research Themes

  • CCN proteins in cardiovascular disease, uterine fibroids, asthma and other smooth muscle cell-based diseases
  • Regulation of smooth muscle cell proliferation

Recent Publications

  • Gray MR, Malmquist JA, Sullivan M, Blea M, and Castellot JJ
    CCN5 Expression in Mammals. II. Adult Rodent Tissues
    J. Cell Commun. Signal. 2007; 1:145-158
  • Malmquist JA, Gray MR, Oliveira, BE, Koch M, and Castellot JJ
    CCN5 Expression in Mammals. I. Embryonic and Fetal Tissues of Human and Mouse
    J. Cell Commun. Signal. 2007; 1:127-14
  • Gray M and Castellot JJ
    Regulation of Smooth Muscle Cell Growth
    Uterine Fibroids: Pathogenesis and Management. Brosens I, ed. London: Taylor and Francis, 2006; pp. 25-41.
  • Gray M and Castellot JJ
    Biology and Pathophysiology of CCN5
    The CCN Family of Proteins. Perbal B, and Takigaw M. eds. Imperial College Press, 2005; pp. 247-265.
  • Mason HR, Wubben M, Nowak RA, Lake AC, and Castellot JJ
    The growth arrest-specific gene CCN5 is deficient in human leiomyomas and inhibits the proliferation and motility of cultured human uterine smooth muscle cells
    Molec Human Reproduction 2004; 10:1-7.
  • Mason HR, Grove-Strawser D, Nowak RA, Rubin R, and Castellot JJ
    Estrogen induces CCN5 expression in the rat uterus in vivo.
    J Endocrinology 2004; 145: 976-982.
  • Lake AC and Castellot JJ
    CCN5 modulates the antiproliferative effect of heparin and regulates cell motility in vascular smooth muscle cells
    Cell Commun. Signal. 2004; 1:5-12.
  • Lake AC and Castellot JJ
    CCN5 is a growth arrest-specific gene that inhibits vascular smooth muscle cell proliferation and motility
    Amer J Pathol. 2003; 162: 219-231
  • Mishra-Gorur K, Singer H and Castellot JJ
    The S18 ribosomal protein is a putative substrate for Ca2+/calmodulin-activated protein kinase II in vascular smooth muscle cells
    J Biol Chem. 2002; 277:33527-40