The International CCN Society

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HÂvard Attramadal

HÂvard Attramadal, M.D., Ph.D.
Institute for Surgical Research and Center
for Heart Failure Research
Oslo University Hospital and University of Oslo
Sognsvannsveien 20
P.O. Box 4950 Nydalen
NO-0424 Oslo NORWAY
Tel: +47-23073520
Fax: +47-23073530

Present Position

  • Professor of Medicine (Molecular and Cellular Cardiology), University of Oslo
  • Investigator, Center for Heart Failure Research, University of Oslo
  • Vice-Chair, Institute for Surgical Research, Oslo University Hospital


  • International CCN Society
  • American Heart Association (Fellow)
  • European Society of Cardiology (ESC)
  • ESC ñ Working Group on Myocardial Function (Nucleus Member 2006-2010)
  • The Norwegian Society of Cardiology
  • The Norwegian Medical Association
  • The Norwegian Society of Biochemistry


  • NIH/Fogarty International Research Fellowship Award 1990-1992
  • Unger-Vetlesen Medical Fund Fellowship Award 1993
  • Research Council of Norway Established Investigator 1994-1996
  • Professor Ole Storstein Prize for Research in Cardiology 1996

Research Themes

  • The role of CCN proteins in cardiac tolerance towards ischemia-reperfusion injury, cardiac repair and regeneration after myocardial infarction, and in myocardial remodeling in heart failure.
  • Signaling mechanisms of CCN proteins.
  • Role of CCN proteins in cardiac fibroblast differentiation and function.

Selected Recent Publications

  • Bremnes, T., Paasche, J.D., Mehlum, A., Sandberg, C., and Attramadal, H.
    Regulation and Intracellular Trafficking Pathways of The Endothelin Receptors.
    J Biol Chem 275: 17596-17604, 2000.
  • Paasche, J.D., Attramadal, T., Sandberg, C., J., Johansen, H.K. and Attramadal, H.
    Mechanisms of Endothelin Receptor Subtype-Specific Targeting to Distinct Intracellular Trafficking Pathways.
    J Biol Chem 276: 34041-34050, 2001.
  • Ahmed, M.S., ÿie, E., Vinge, L.E., Yndestad, A., Andersen, G.ÿ., Andersson, Y., Attramadal, T., and Attramadal, H.
    Connective Tissue Growth Factor ñ A Novel Mediator of Angiotensin II-Mediated Cardiac Fibroblast Activation in Heart Failure in Rats.
    J Mol Cell Cardiol 36: 393-404, 2004.
  • Yndestad, A., Ueland, T., ÿie, E., Florholmen, G., Attramadal, H., Simonsen, S., Fr¯land, S.S., Gullestad, L., Christensen, G., DamÂs, J.K., and Aukrust, P.
    Elevated Levels of Activin A in Chronic Heart Failure ñ Potential Role in Myocardial Remodeling.
    Circulation 109: 1379-1385, 2004.
  • Ahmed, M.S., von Lueder, T.G., ÿie, E., Kjekshus, H., and, Attramadal, H
    Induction of Myocardial Connective Tissue Growth Factor in Pacing-Induced Heart Failure in Pigs.
    Acta Physiol Scand 184: 27-36, 2005.
  • Paasche, J.D., Attramadal, T., Kristiansen, K., Oksvold, M.P., Johansen, H., Huitfeldt, H., Dahl, S.G., and Attramadal, H.
    Subtype-Specific Sorting of The ETA Endothelin Receptor by A Novel Endocytic Recycling Signal for G Protein-Coupled Receptors.
    Mol Pharmacol 67: 1581-1590, 2005.
  • Ahmed, M.S., ÿie, E., Vinge, L.E., von Lueder, T.G., Attramadal, T., and Attramadal, H.
    Induction of Pulmonary Connective Tissue Growth Factor (CTGF) in Heart Failure Is Associated with Pulmonary Parenchymal and Vascular Remodeling.
    Cardiovasc Res 74:323-333, 2007.
  • Vinge, L.E., Andressen, K.W., Attramadal, T., Andersen, G.ÿ., Ahmed, M.S., Peppel, K., Koch, W.J., Freedman, N.J., Levy, F.O., Skomedal, T., Osnes, J.B., and Attramadal, H.
    Substrate Specificities of G Protein-Coupled Receptor Kinase-2 and -3 at Cardiac Myocyte Receptors Provide Basis for Distinct Roles in Regulation of Myocardial Function.
    Mol Pharmacol 72: 582-591, 2007.
  • Vinge, L.E., von Lueder, T.G., Aasum, E., Qvigstad, E., Gravning J.A., How, O.J., Edvardsen, T., Bj¯rnerheim, R., Ahmed, M.S., Mikkelsen, B.W., ÿie, E., Attramadal, T., Smiseth, O.A., Koch, W.J., Larsen, T.S., and Attramadal, H.
    Cardiac-Restricted Expression of The Carboxyl-Terminal Fragment of GRK3 Uncovers Distinct Functions of GRK3 in Regulation of Cardiac Contractility and Growth ñ GRK3 controls cardiac ?1-adrenergic receptor responsiveness.
    J Biol Chem 283: 10601-10610, 2008.
  • Bergestuen, D.S., Gravning, J., Haugaa, K.H., Sahakyan, L., Aakhus, S., Thiis-Evensen, E., ÿie, E., Aukrust, P., Attramadal, H., and Edvardsen, T.
    Plasma CCN2/Connective Tissue Growth Factor is Associated with Right Ventricular Dysfunction in Patients with Neuroendo-crine Tumors.
    BMC Cancer. 10:6, 2010.
  • Ahmed, M.S., Gravning, J., Martinov, V.N., von Lueder, T.G., Edvardsen, T., Czibik, G., Moe, I.T., Vinge, L.E., ÿie, E., Valen, G., and Attramadal, H.
    Mechanisms of Novel Cardioprotective Functions of CCN2/CTGF in Myocardial Ischemia-Reperfusion Injury.
    Am J Physiol Heart Circ Physiol. 300: H1291-H1302, 2011.
  • Gravning J., ÿrn, S., Kaasb¯ll, O.J., Martinov, V.N., Manhenke, C., Dickstein, K., Edvardsen, T., Attramadal, H., and Ahmed, M.S.
    Myocardial Connective Tissue Growth Factor (CCN2/CTGF) Attenuates Left Ventricular Remodeling After Myocardial Infarction.
    PLoS One. 7(12):e52120, 2012.
  • Moe, I.T., Pham, T.A., Hagelin, E.M.V., Ahmed, M.S., and Attramadal, H.
    CTGF/CCN2 Exerts Direct Cytoprotective Actions in Adult Cardiac Myocytes by Activation of the PI3-kinase/Akt/GSK-3? Signaling Pathway.
    J Cell Commun Signal. 7(1):31-47, 2013.
  • Gravning J., Ahmed, M.S., von Lueder, T.G., Edvardsen, T., and Attramadal, H.
    CCN2/CTGF attenuates myocardial hypertrophy and cardiac dysfunction upon chronic pressure-overload.
    Int J Cardiol. 168(3):2049-2056, 2013.
  • Gravning, J., Ahmed, M.S., Qvigstad, E., Krobert, K., Edvardsen, T., Moe, I.T., Hagelin, E.M.V., Sagave, J., Valen, G., Levy, F.O., Osnes, J.-B., Skomedal, T., and Attramadal, H.
    Connective Tissue Growth Factor/CCN2 Attenuates ?-Adrenergic Receptor Responsiveness and Cardiotoxicity by Induction of G Protein-Coupled Receptor Kinase-5 in Cardiomyocytes.
    Mol Pharmacol. 84(3):372-383, 2013.