The International CCN Society

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Gary Fisher


Gary J. Fisher, PhD.
Department of Dermatology
University of Michigan
6447 Med Sci I, 1301 E Catherine,
Ann Arbor, Michigan, USA 48109
Tel: 734-763-1469
Fax: 734-647-0076

Present Position

  • Harry Helfman Professor of Molecular Dermatology, Department of Dermatology, University of Michigan


  • International CCN Society
  • Society for Photobiology
  • American Association for the Advancement of Science
  • American Society for Biochemistry and Molecular Biology
  • Society for Investigative Dermatology
  • Skin Pharmacology
  • American Society for Matrix Biology


  • University of California Presidents Research Award 1974
  • University of Michigan Inventor Recognition Award 2001
  • University of Michigan Medical School Dean’s Award for Achievement in Clinical and Basic Science Research 2001
  • Harry Helfman Professor of Molecular Dermatology 2008

Editorial Boards

  • Journal for Investigative Dermatology (Associate Editor)
  • Journal of Dermatological Science (Board Member)

Research Themes

  • CCN1, a potential mediator of photoaged human skin
  • Collagenase degradation of extracellular matrix
  • Regulation of extracellular matrix homeostasis by CCN2 in skin aging
  • TGF-beta signaling in photoaged and chronologically aged human skin

Selected Recent Publications

  • Xu Y and Fisher GJ
    Ultraviolet (UV) light irradiation induced signal transduction in skin photoaging.
    J Dermatol Sci, 1:S1-S8, 2005.
  • Rittie L, Fisher GJ
    Isolation and culture of skin fibroblasts.
    Methods Molecular Medicine 117:83-98, 2005.
  • Fisher GJ
    The pathophysiology of photoaging of the skin.
    Cutis 75(2 suppl):5-8, 2005
  • Xu Y, Tan LJ, Grachtchouk V, Voorhees JJ, Fisher GJ
    Receptor-type protein-tyrosine phosphatase-k regulates epidermal growth factor receptor function.
    J Biol Chem 280:42694-42700, 2005.
  • Varani J, Dame MK, Rittie L, Fligiel SE, Kang S, Fisher GJ, Voorhees JJ
    Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation.
    Amer J Pathol 168:1861-1868, 2006.
  • Quan T, He T, Shao Y, Lin L, Kang S, Voorhees JJ, Fisher GJ
    Elevated cysteine-rich 61 mediates aberrant collagen homeostasis in chronologically aged and photoaged human skin.
    Amer J Pathol 169:482-490, 2006.
  • Orringer JS, Hammerberg C, Lowe L, Kang S, Johnson TM, Hamilton T, Voorhees JJ, Fisher GJ
    The effects of laser-mediated hair removal on immunohistochemical staining properties of hair follicles.
    Amer Acad Dermatol 55:402-407, 2006.
  • Karimipour DJ, Kang S, Johnson TM, Orringer JS, Hamilton T, Hammerberg C, Voorhees, JJ, Fisher GJ
    Microdermabrasion with and without aluminum oxide crystal abrasion: a comparative molecular analysis of dermal remodeling.
    J Am Acad Dermatol 54:405-410, 2006.
  • Rittie L, Varani J, Kang S, Voorhees JJ, Fisher GJ
    Retinoid-induced epidermal hyperplasia is mediated by epidermal growth factor receptor activation via specific induction of its ligand heparin-binding EGF and amphiregulin in human skin in vivo.
    J Invest Dermatol 126:732-739, 2006.
  • Xu Y, Voorhees JJ, Fisher GJ
    Epidermal growth factor receptor is a critical mediator of ultraviolet B irradiation-induced signal transduction in immortalized human keratinocyte HaCaT cells.
    Amer J Pathol 169:823-830, 2006.
  • Xu Y, Shao Y, Voorhees JJ, Fisher GJ
    Oxidative inhibition of receptor-type protein-tyrosine phosphatase kappa by ultraviolet irradiation activates epidermal growth factor receptor in human keratinocytes.
    J Biol Chem 281:27389-27397, 2006.
  • Wang F, Garza LA, Kang S, Varani J, Orringer JS, Fisher GJ, Voorhees JJ
    In vivo stimulation of de novo collagen production caused by cross-linked hyaluronic acid dermal filler injections in photodamaged huam skin.
    Arch Dermatol 143:155-163, 2007.
  • Bleau, AM, Planque N, Lazar N, Zambelli D, Ori A, Quan TH, Fisher G, Scotlandi K, Perbal B: Antiproliferative activity of CCN3
    involvement of the C-terminal module and post-translational Regulation. J Cell Biochem 101:1475-1491, 2007.
  • Rittie L, Kansra S, Stoll SW, Li Y, Gudjonsson JE, Shao Y, Michael LE, Fisher GJ, Johnson TM, Elder JT
    Differential Erb1 signaling in squamous cell verus basal cell carcinoma of the skin.
    Amer J Pathol 170:2089-2099, 2007
  • Kafi R, Kwak HS, Schumacher WE, Cho S, Hanft VN, Hamilton TA, King AL, Neal JD, Varani J, Fisher GJ, Voorhees JJ, Kang S
    Improvement of naturally aged skin with vitamin A (retinol).
    Arch Dermatol 143:606-612, 2007.
  • Varani J. Perone P. Warner RL. Dame MK. Kang S. Fisher GJ. Voorhees JJ
    Vascular tube formation on matrix metalloproteinase-1-damaged collagen.
    British J Cancer. 98(10):1646-52, 2008.
  • Fisher GJ, Varani J, Voorhees JJ
    Looking older: fibroblast collapse and therapeutic implications.
    Arch Dermatol 144(5):666-72, 2008.
  • Rittié L, Kang S, Voorhees JJ, Fisher GJ
    Induction of collagen by estradiol: difference between sun-protected and photodamaged human skin in vivo.
    Arch Dermatol, 144(9):1129-1140, 2008.
  • Wang F, Garza LA, Cho S, Kafi R, Hammerberg C, Quan T, Hamilton T, Mayes M, Ratanatharathorn V, Voorhees JJ, Fisher GJ, Kang S
    Effect of increased pigmentation on the anitfibrotic response of human skin in UV-A1 phototherapy.
    Arch Dermatol 144(7):851-858, 2008.
  • Fisher GJ, Quan T, Purohit T, Shao Y, Cho MK, He T, Varani J, Kang S, Voorhees JJ
    Collagen fragmentation promotes oxidative stress and elevates matrix metalloproteinase-1 in fibroblasts in aged human skin.
    Amer J Pathol, 174(1):101-114, 2009.
  • Rittié L, Stoll SW, Kang S, Voorhees JJ, Fisher GJ
    : Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin.
    Aging Cell, 8: 738-751, 2009.
  • Karimipour DJ, Rittié L, Hammerberg C, Min VK, Voorhees JJ, Orringer JS, Sachs DL, Hamilton T, Fisher GJ
    Molecular analysis of aggressive microdermabrasion in photoaged skin.
    Arch Dermatol. 145(10):1114-22, 2009.
  • Quan T, Qin Z, Xia W, Shao Y, Voorhees JJ, Fisher GJ
    Matrix-degrading metalloproteinases in photoaging.
    J Investig Dermatol Symp Proc. 14(1):20-4. Review, 2009.
  • Bhagavathula N, DaSilva M, Aslam MN, Dame MK, Warner RL, Xu Y, Fisher GJ, Johnson KJ, Swartz R, Varani J
    Regulation of collagen turnover in human skin fibroblasts exposed to a gadolinium-based contrast agent.
    Invest Radiol. 44(8):433-9, 2009.
  • Do TT, Bailey EC, Wang F, Smith N, Lee W, Fisher GJ, Voorhees JJ, Kang S
    Targeted broadband ultraviolet B phototherapy improves disorders characterized by increased dermal matrix.
    Br J Dermatol. 161(6):1405-1407, 2009.
  • Quan T, Shao Y, He T, Voorhees JJ, Fisher GJ
    Reduced Expression of Connective Tissue Growth Factor (CTGF/CCN2) Mediates Collagen Loss in Chronologically Aged Human Skin.
    J Invest Dermatol. 130(2):415-424, 2010.
  • Xu Y, Baker D, Quan T, Baldassare JJ, Voorhees JJ, Fisher GJ
    Receptor Type Protein Tyrosine Phosphatase-Kappa (RPTP-k) Mediates Cross-Talk between TGF-ß and EGFR Signaling Pathways in Human Keratinocytes.
    Mol Biol Cell. 21(1):29-35, 2010.
  • Quan T, Qin Z, Xu Y, He T, Kang S, Voorhees JJ, Fisher GJ
    Ultraviolet irradiation induces CYR61/CCN1, a mediator of collagen homestasis, through activation of transcription factor AP-1 in human skin fibroblasts.
    J Invest Dermatol. 2010, 130(6):1697-1706.
  • Quan T, Qin Z, Shao Y, Xu Y, Voorhees JJ, Fisher GJ
    Retinoids Suppress Cysteine-rich Protein 61 (CCN1), a Negative Regulator of Collagen Homeostasis, in Skin Equivalent Cultures and Aged Human Skin in vivo.
    In press, 2011.