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David R. Brigstock

David R. Brigstock, Ph.D.

Nationwide Children's Hospital
700 Children's Drive
Columbus Ohio 43205 USA
Tel: 1 614-355-2824

Fax: 1 614-722-5892

Present Position

  • Principal Investigator, Center for Clinical and Translational Research,  Nationwide Children’s Hospital, Columbus Ohio 43205
  • Professor, Division of Pediatric Surgery, Department of Surgery,
Ohio State University
Columbus Ohio 43212


  • Society of Biology (Fellow)
  • International CCN Society (liaison for Hepathology societies)
  • American Association for the Study of Liver Diseases
  • International Society for Hepatic Sinusoidal Research
  • American Society for Cell Biology
  • Society of University Surgeons (elected)


  • Review Editor, Journal of Cell Communication and Signaling
  • Editorial board member, Journal of Cell Communication and Signaling

Research Themes

  • Exosome regulation of hepatic fibrosis
  • Exosomal microRNA in hepatic stellate cell function
  • Exosomes in liver fibrosis therapy
  • Non-invasive fibrosis assessment using exosome payloads

Selected Recent Publications

  • Chen L and Brigstock DR
    Cellular or exosomal microRNAs associated with CCN gene expression in liver fibrosis..
    Methods Mol Biol. 2017 1489 465-480 PMID: 27734397
  • Chen L and Brigstock DR
    Analysis of pathological activities of CCN proteins in fibrotic diseases: Liver fibrosis..
    Methods Mol Biol. 2017 489 445-463 PMID: 27734396
  • Chen L, Brigstock DR
    Integrins and heparan sulfate proteoglycans on hepatic stellate cells (HSC) are novel receptors for HSC-derived exosomes..
    FEBS Letts 2016 Oct 7. doi: 10.1002/1873-3468.12448. [Epub ahead of print] PMID: 27714787
  • Thompson MD, Cismowski C, Trask AJ, Lallier SE, Graf AE, Rogers LK,Lucchesi PA, Brigstock DR
    Enhanced steatosis and fibrosis in liver of offspring exposed to maternal high fat diet..
    Gene Expression: The Journal of Basic Liver Research 2016 17 47-59. PMID: 27342733
  • Chen L, Chen R, Velazquez VV, Brigstock DR
    Fibrogenic signaling is suppressed in hepatic stellate cells through targeting of connective tissue growth factor (CCN2) by cellular or exosomal microRNA-199a-5p. .
    Am J Pathol 2016 186 2921-2933. PMID: 27662798
  • Chen L, Chen R, Kemper S, Charrier A, Brigstock DR
    Suppression of fibrogenic signaling in hepatic stellate cells by Twist1-dependent microRNA-214 expression: Role of exosomes in horizontal transfer of Twist1..
    American Journal of Physiology: Gastrointestinal and Liver Physiology 2015 309 G491-499 PMID:26229009.
  • Riley KG, Pasek RC, Maulis MF, Peek J, Thorel F, Brigstock DR, Herrera PL, Gannon M
    CTGF modulates adult β-cell maturity and proliferation to promote β-cell regeneration.
    Diabetes 2015 64 1284-1298 PMID 25392241
  • Charrier A, Chen R, Chen L, Kemper S, Hattori T, Takigawa M, Brigstock DR
    Exosomes mediate intercellular transfer of pro-fibrogenic connective tissue growth factor (CCN2) between hepatic stellate cells, the principal fibrotic cells in the liver..
    Surgery doi: 10.1016/j.surg.2014.04.014, PMID 24882759
  • Charrier A, Chen R, Chen L, Kemper S, Hattori T, Takigawa M, Brigstock DR
    Connective tissue growth factor (CCN2) and microRNA-21 are components of a positive feedback loop in pancreatic stellate cells (PSC) during chronic pancreatitis and are exported in PSC-derived exosomes..
    J Cell Comm Signal 2014 8 147-156 PMID 24464300
  • Charrier, A, Chen R, Kemper S, Brigstock DR
    Regulation of pancreatic inflammation by connective tissue growth factor (CTGF/CCN2).
    Immunology 2014 141 564-576 PMID: 24754049
  • Charrier, A, Chen R, Kemper S, Brigstock DR (2014)
    Regulation of pancreatic inflammation by connective tissue growth factor (CTGF/CCN2)
    Immunology 141 564-576 PMID: 24754049
  • Chen L, Charrier A, Zhou Y, Yu B, Agarwal K, Tsukamoto H, Lee LJ, Paulaitis ME, Brigstock DR (2013)
    Epigenetic regulation of connective tissue growth factor by delivery of microRNA-214 in exosomes from mouse or human hepatic stellate cells 
    Hepatology DOI:10.1002/hep.26768.
  • Abbott RD, Purmessur D, Monsey RD, Brigstock DR, Iatridis JC (2013)
    Degenerative Grade Affects the Responses of Human Nucleus Pulposus Cells to Link-N, CTGF, and TGF-β3.
    Journal of Spinal Disorders and Techniques 26 E86-94 PMID: 22907063
  • Charrier A and Brigstock DR (2013)
    Regulation of pancreatic function by connective tissue growth factor (CTGF,CCN2).
    Cytokine and Growth Factor Reviews  24 59-68 PMID: 22884427
  • Huang G, Brigstock DR (2012)
    Regulation of hepatic stellate cells by connective tissue growth factor
    Frontiers Biosci  17 2495-2507 PMID: 22652794
  • Xiu M, Liu Y-H, Brigstock DR, He F-H, Zhang R-J, Gao R (2012)
    Connective Tissue Growth Factor is overexpressed in human hepatocellular carcinoma and promotes cell invasion and growth.
    World J Gastro 18 7070-7078 PMID: 23323010; PMCID:PMC3531696
  • Tirumuru, N. Chen L, Balasubramanian A, Groopman JE, Ghoshai K, Jacob ST, Brigstock DR, Anand A, Ganju RK (2012)
    Activation of the connective tissue growth factor (CTGF) - transforming growth factor β (TGF-β) axis in hepatitis C virus-expressing hepatocytes.
    PLoS One 7(10):e46526 doi: 10.1371/journal.pone.0046526 PMID:23056332 (co-senior author)
  • Piao R-L, Brigstock, D, Zhu J, Zhang M-L, Gao R, (2012)
    The clinical significance of connective tissue growth factor in hepatitis B virus-induced hepatic fibrosis.
    World J Gastro 18 2280-286 PMID: 22611323; PMCID: PMC3351780
  • Huang G, Besner G, Brigstock DR (2012)
    Heparin-binding epidermal growth factor-like growth factor suppresses experimental liver fibrosis in mice 
    Lab Invest  92 703-712 PMID: 22330337; PMCID: PMC3338873
  • Chen L, Charrier AL, Leask A, French S Brigstock DR (2011)
    Ethanol-stimulated differentiated functions of human or mouse hepatic stellate cells are mediated by connective tissue growth factor.
    J Hepatol 55 399-406 PMID: 21156189; PMCID: PMC3136646
  • Ezzie ME,Piper MG, Montague C, Newland CA, Opalek JM, Baran C, Ali N, Brigstock D, Lawler P, Marsh CB (2011)
    Thrombospondin-1 deficient mice are not protected from bleomycin-induced pulmonary fibrosis.
    Am J Resp Cell Mol Biol 44 556-561 PMID: 20581099; PMCID: PMC3095927
  • Huang G, Brigstock DR (2011)
    Integrin expression and function in the response of primary culture hepatic stellate cells to connective tissue growth factor (CCN2)
    J. Cell. Mol. Med. 15 1087-1095 PMID: 20406330; PMCID: PMC2912974
  • Charrier A and Brigstock DR (2010)
    Connective tissue growth factor production by activated pancreatic stellate cells in mouse alcoholic chronic pancreatitis.
    Lab Invest 90 1179-1188 PMID: 20368699; PMCID: PMC2901405
  • Brigstock DR (2010)
    Connective tissue growth factor (CCN2, CTGF) and organ fibrosis: Lessons from transgenic animals.
    J. Cell Comm. Signal 4 1-4 PMID: 19798591; PMCID: PMC2821473
  • Gao R and Brigstock DR (2009)
    Connective tissue growth factor hammerhead ribozyme attenuates human hepatic stellate cell function.
    World J Gastroenterology 15 3807-3813 PMID: 19673024; PMCID: PMC2726461
  • Brigstock DR (2009)
    Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo.
    J. Cell Comm Signal 3 5-18 PMID: 19294531; PMCID: PMC2686750
  • Tong Z, Chen R, Kemper S, Perbal B, and Brigstock DR (2009)
    Susceptibility to liver fibrosis in mice expressing a connective tissue growth factor transgene in hepatocytes
    Hepatology 50 939-947 PMID: 19670427; PMCID: PMC2737071