The International CCN Society

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Akira Yamaguchi

Akira Yamaguchi, D.D.S., Ph.D.
Department of Oral Pathology
Graduate School of Medical and Dental Sciences
Tokyo Medical and Dental University
1-5-45 Yushima, Bunkyo-ku,
Tokyo 113-8549 Japan
Tel: +81-3-5803-5451
Fax: +81-3-5803-0188
akira.mpa@tmd.ac.jp

Present Positions

  • Professor of Oral Pathology,
    Graduate School of Medical and Dental Sciences
    Tokyo Medical and Dental University
  • Member of council, Tokyo Medical and Dental University

Societies

  • Japanese Society of Pathology (Board of Director)
  • Japanese Society of Oral Pathology (President)
  • Japanese Bone and Mineral Research Society (Board of Director, Vice President 2004-2008)
  • Japan Society for Oral Tumors (Board of Director)
  • American Society of Bone and Mineral Research
  • International Bone and Mineral Society

Editorial Boards

  • Bone (1994-present)
  • Journal of Bone and Mineral Metabolism (1994-2006), associate editor (2006-2012)
  • Pathology International (1998-2001)
  • Oral Medicine and Pathology (1998-present)
  • Odontologia (2000-present)
  • Journal of Orthopaedic Science (2000-present)
  • Oral Science International (2004-present)

Awards

  • The Japanese Society for Bone and Mineral Research: Academic Award (1993)
  • The Japanese Society of Pathology: Pathology Research Award (1996)
  • The Japanese Pathology Award (2005)

Research Themes

  • Molecular mechanism of osteoblast differentiation and bone formation
  • Molecular mechanism of bone regeneration
  • Integrin-mediated matrix signaling
  • Mechanism of bone destruction by oral cancer
  • Evolutional changes in skeletal tissues

Selected Recent Publications

  • Matsushita Y, Sakamoto K, Tamamura Y, Shibata Y, Minamizato T, Kihara T, Ito M, Katsube K, Hiraoka S, Koseki H, Harada K, Yamaguchi A
    CCN3 protein participates inbone regeneration as an inhibitory factor.
    J Biol Chem 288:19973-19985,2013
  • Hoshino A, Ueha S, Hanada S, Imai T, Ito M, Yamamoto K, Matsushima K, Yamaguchi A, Iimura T
    Roles of chemokine receptor CX3CR1 in maintaining murine bone homeostasis through the regulation of both osteoblasts and osteoclasts.
    J Cell Sci 126:1031-1045,2013
  • Matsumoto T, Iimura T, Ogura K, Moriyama K, Yamaguchi A
    The role of osteocytes in bone resorption during orthodontic tooth movement. J Dent Res 92:340-345, 2013
  • Sato K, Lee JW, Sakamoto K, Iimura T, Kayamori K, Yasuda H, Shindoh M, Ito M, Omura K, Yamaguchi A
    RANKL synthesized by both stromal cells and cancer cells plays a crucial role in osteoclastic bone resorption induced by oral cancer.
    Amer J Pathol 182:1890-1899,2013
  • Shimada Y, Katsube K, Kabasawa Y, Morita K, Omura K, Yamaguchi A, Sakamoto K
    Integrated genotypic analysis of hedgehog-related genes identifies subgroups of keratocystic odontogenic tumor with distinct clinicopathological features.
    Plos One 8:e70995, 2013
  • Watanabe T, Tamamura Y, Hoshino A, Makino Y, Nishimura R, Kamioka H, Yoneda T, Amagasa T, Yamaguchi A, Iimura T
    v Increasing participation of Sclerostin in postnatal bone development revealed by three-dimensional immunofluorescence morphometry.
    BONE 51:447-458,2012
  • Sakamoto K, Fujii T, Kawachi H, Miki Y, Omura K, Morita K, Kayamori K, Khanom R, Katsube K, Yamaguchi A
    Reduction of NOTCH1 expression pertains to maturation abnormalities of keratinocytes in squamous neoplasms.
    Lab Invest 92:688-702:2012
  • Kayamori K, Sakamoto K, Nakashima T, Takayanagi T, Morita K, Omura K, Nguyen ST, Miki Y, Iimura T, Himeno A, Akashi T, Yamada-Okabe H, Ogata E, Yamaguchi A
    Roles of IL-6 and PTHrP in osteoclast formation associated with oral cancers: The significance of IL-6 synthesized by stromal cells in response to cancer cells.
    Amer J Pathol 176,968-980,2010
  • Nishikawa K, Isogai M, Nakashima T, Takeda S, Michito, Hamada M, Kimura A, Kodama T, Yamaguchi A, Owen MJ, Takahashi S, Takayanagi H
    Maf mediates the age-related switch in mesenchymal cell.
    J Clin Invest 120:3455-3465,2010
  • Katsube K, Ichikawa S, Katsuki Y, Kihara T, Terai M, Lau LF, Tamamura Y, Takeda S, Umezawa A, Sakamoto K, Yamaguchi A
    CCN3 and bone marrow cells.
    J Cell Commun Signal. 3:135-145,2009
  • Katsuki Y, Sakamoto K, Minamizato T, Umezawa A, Ikeda M, Perbal B, Amagasa T, Yamaguchi A, Katsube K
    Dual role of CCN3/Notch signal in mouse osteogenic mesenchymal stem cells, Kusa.
    Biochem Bioph Res Co 368:808-814,2008
  • Minamizato T, Sakamoto K, Liu T, Kokubo H, Katsube K, Perbal B, Nakamura S, Yamaguchi A
    CCN3/NOV inhibits BMP-2-induced osteoblast differentiation by interacting with BMP and Notch signaling pathways.
    Biochem Bioph Res Co 354:567-573,2007
  • Aoki K, Saito H, Itzstein C, Ishiguro M, Shibata T, Blanque R, Hussain A, Takahashi M, Suzuki Y, Yoshimatsu M, Yamaguchi A, Deprez P, Murali R, Ohya K, Horne W, Baron R
    A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption and bone loss" (22513-RG-RV-2).
    J Clin Invest 116:1525-1534,2006
  • Sato K, Okamoto K, Suematsu A, Yamaguchi A, Morishita Y, Kadono Y, Tanaka S, Kodama T, Akira S. Iwakura Y, Cua DJ, Takayanagi H
    Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction.
    J Exp Med 203:2673-2682, 2006
  • Sato K, Suematsu A, Nakashima T, Takemoto-Kimura S, Aoki K, Morishita Y, Asahara H, Ohya K, Yamaguchi A, Takai T, Kodama T, Chatila TA, Bito H, Takayanagi H
    Regulation of osteoclast differentiation and function by the CaMK/CREB pathway.
    Nat Med 12, 1410-1416, 2006
  • Moriishi T, Shibata Y, Tsukazaki T, Yamaguchi A
    Expression profile of Xenopus banded hedgehog, a homolog of mouse Indian hedgehog, is related to the late development of endochondral ossification in Xenopus laevis.
    Biochem Bioph Res Co 328:867-873, 2005
  • Nobta M, Tsukazaki T, Shibata Y, Chang X, Moriishi T, Sakano S, Shindo H, Yamaguchi A
    Critical regulation of BMP-induced osteoblastic differentiation by Delta1/Jagged1-activatedNotch1 signaling. J Biol Chem 280:15842-15848,2005 • Yamaguchi A, Komori T, Suda T: Regulation of Osteoblast Differentiation Mediated by BMPs, Hedgehogs and Cbfa1.
    Endocrine Reviews 21:393-411,2000
  • Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, Shimuzu Y, Bronson RT, Gao Y-H, Inada M, Sato M, Okamoto R, Tominaga K, Kitamura Y, Yoshiki S, Kishimoto T
    Targeted disruption of Cbfa1 results in complete lack of bone formation owing to the maturation arrest of osteoblasts.
    Cell 89:755-764,1997
  • Ishizuya T, Yokose S, Hori M, Noda T, Suda T, Yoshiki S, Yamaguchi A
    Parathyroid hormone exerts disparate effects on osteoblast differentiation depending on exposure time in rat osteobllastic cells.
    J Clin Invest 99:2961-2970,1997
  • Katagiri T, Yamaguchi A, Komaki M, Abe E, Takahashi N, Ikeda T, Rosen V, Wozney JM, Fujisawa-Sehara A, Suda T
    Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage.
    J Cell Biol 127:1755-1766, 1994
  • Yamaguchi A, Katagiri T, Ikeda T, Wozney JM, Rosen V, Wang EA, Kahn AJ, Suda T, Yoshiki S
    Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro.
    J Cell Biol 111:681- 687, 1991